Polydnavirus Histone H4 and its role in insect immunity: Polydnavirus Histone H4 - Softcover

Gad, Wael; Kim, Yonggyun

Softcover

ISBN 10: 3659243981 ISBN 13: 9783659243981

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Cotesia plutellae (Braconidae: Hymenoptera) is a solitary endoparasitoid wasp that parasitizes the diamondback moth, Plutella xylostella (L.) (Yponomeutidae: Lepidoptera). For successful parasitization, its symbiotic polydnavirus (CpBV) helps the wasps to attenuate host immune capacity and manipulate host developmental physiology. An analysis of CpBV genome sequence indicated the presence of one putative gene (CpBV-H4) showing a high similarity to histone H4. Histone H4, one of the four histone subunits along with H2A, H2B and H3, forms an eukaryotic nucleosome core. Along with H3, it plays a central role in nucleosome formation. CpBV-H4 showed expression in different tissues in parasitized P. xylostella. Transient expression of CpBV-H4 in nonparasitized P. xylostella resulted in significant impairment of hemocyte-spreading and decreased gene expression of host H4, while knock-down of the transient expression using double-stranded RNA interference recovered the immune capacity and gene expression.

About this title

About the Author

Wael Gad is PhD Researcher, Department of Structure Biology at Vrije University Brussels. Master of Science, Department of Bioresource Sciences, Andong National University, South Korea. B.Sc. of Zoology, Department of Zoology and Marine Biology, Al-Azhar University Assiut, Egypt.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3659243981
• ISBN 13: 9783659243981
• Binding: Paperback
• Number of pages: 88