Biotechnology: A Multi–Volume Comprehensive Treatise Recombinant Proteins, Monoclonal Antibodies, and Therapeutic Genes: v.5 - Hardcover

Mountain, A.; Ney, U. M.; Schomburg, Dietmar

Hardcover

ISBN 10: 3527283153 ISBN 13: 9783527283156

Publisher: Wiley VCH, 1998

Synopsis

In the field of medicinal biotechnology, three major developments have caused a revolution in research that has a lot of innovative effects on clinical medicine and future applications on humans. With the availability of tailored recombinant proteins and the opportunity to produce high amounts of monoclonal antibodies, new diagnostic applications have emerged and many therapeutic perspectives, for example, in the treatment of multiple sclerosis and of cancer, are being discussed today. The aim of somatic gene therapy is to re-establish normal cell function by supplying the cells with the respective intact gene. This is a very difficult task and different diseases, for example, AIDS and several metabolic disorders, are under investigation now. So far, first promising approaches exist in cancer therapy. Moreover the book informs about regulatory and economic aspects of these new methods and their applications.

About this title

From the Back Cover

Biotechnology Second, Completely Revised Edition Edited by H.-J. Rehm and G. Reed in cooperation with A. Pühler and P. Stadler This fully revised and expanded Second Edition takes into account all recent developments in biotechnology. It is extraordinarily broad in scope, up-to-date, carefully structured and well-balanced. "Biotechnology" considers both basic concepts and widely-differing industrial applications: it is a successful synthesis of theory and practice. Any scientist aiming for success in industrial microbiology, biochemistry, molecular biology and chemical engineering must turn to "Biotechnology". Volume 5a: Proteins are the molecules of choice when highly specific medical treatments or other highly specific technical properties are requried. The first chapters provide an overview of protein structure and function and of the design and uses of recombinant proteins. Options and issues of antibody therapies are discussed in chapters ranging from the design and manufacture of antibodies through pre-clinical testing and clinical development. The new approach to treatment of disease by targeted gene therapy is reviewed demonstrating the extent of challenges still to be met before gene therapy products can be used successfully. The rapidly changing global regulatory environment and pharmacoeconomic issues for products of biotechnology are also highlighted. Topics included are: Structure and Function of Proteins • Recombinant Proteins: In vitro Folding • Medical Applications • Industrial Applications • Monoclonal Antibodies: Engineering and Expression • Manufacture • Preclinical Testing • Therapeutic Applications • Case Studies • Gene Therapy: Vectors • Large-Scale Plasmid DNA Manufacturing • Regulatory and Economic Aspects

Edition details

• Publisher: Wiley VCH
• Publication date: 1998
• Language: English
• ISBN 10: 3527283153
• ISBN 13: 9783527283156
• Binding: Hardcover
• Edition number: 2
• Number of pages: 580
• Editor: Rehm Hans–Jürgen, Reed Gerald, Pühler Alfred, Stadler Peter