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Synopsis
Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases.
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Product Description
This is the first evaluative discussion of the use of neurotoxins to produce animal models of Alzheimer's, Parkinson's, Huntington's and other human neurodegenerative diseases. The work also responds to criticisms of the use of animals in biomedical research by examining the utility, validity, and limitations of the models presented. An excellent resource for researchers and students in the neurosciences and environmental toxicology interested in both the practical and ethical aspects of animal research.
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Toxin-induced Models of Neurological Disorders
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Toxin-Induced Models of Neurological Disorders
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Toxin-Induced Models of Neurological Disorders
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro degenerative disorders and assessing risk factors associated with neurotoxin ex posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia. 368 pp. Englisch. Seller Inventory # 9781489914491
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Toxin-induced Models of Neurological Disorders
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Toxin-Induced Models of Neurological Disorders
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro degenerative disorders and assessing risk factors associated with neurotoxin ex posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia. Seller Inventory # 9781489914491
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Toxin-Induced Models of Neurological Disorders
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Toxin-Induced Models of Neurological Disorders
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Taschenbuch. Condition: Neu. Toxin-Induced Models of Neurological Disorders | A. J. Nonneman (u. a.) | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2013 | Springer Nature B.V. | EAN 9781489914491 | Verantwortliche Person für die EU: Springer Heidelberg, Tiergartenstr. 17, 69121 Heidelberg, buchhandel-buch[at]springer[dot]com | Anbieter: preigu. Seller Inventory # 105578641
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Toxin-Induced Models of Neurological Disorders
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Condition: New. Print on Demand pp. 368 49:B&W 6.14 x 9.21 in or 234 x 156 mm (Royal 8vo) Perfect Bound on White w/Gloss Lam. Seller Inventory # 133825182
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