Synopsis
Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the 2nd edition of Animal Models in Cardiovascular Research. This completely revised and updated edition will provide information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation will be changed to make the text more easy to read and use: (1) This edition is in outline format, for ease and utility. (2) The opening chapter includes more information on the cardiovascular effects of post-operative analgesia and will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice. (3) New edition includes reference material more useful to researchers using transgenic and naturally occurring animal models to dissect these mechanisms.
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Review
`Every once in a while, one finds a text that is likely to be truly useful and a valuable addition to one's personal library. For those of us involved in cardiovascular research involving the use of whole animal models, such is this text.
Each chapter is prefaced with information of practical value for the researcher. The tables are subdivided by animal species and drug. ... This will be of tremendous value for anybody who is thinking about using a particular animal model for a research project and may save a good deal of time and effort.
For those of us who review grants and manuscripts for publication, this text should serve as a useful reference for normal values and for comparative studies so as to determine whether or not the work in question reflects a typical situation.
... the text is likely to be of considerable use and is highly recommended as an addition to the bookshelves of those of us involved in animal research. It will receive a prominent place in my library.'
Canadian Journal of Anaesthesia, 42:4 (1995)
From the Back Cover
Animal Models in Cardiovascular Research covers both historical and recent advances in our understanding of the cardiovascular system from studies conducted in animal models. The last decade has seen an explosion in the use of very specialized congenic and transgenic animal models that were not described in the previous two editions. The results of many of these studies provide a sometime bewildering array of redundant, overlapping and competing molecular pathways demanding further study. This third edition is designed to provide a better basis for understanding and using animal models in the current climate of background knowledge and information.
The first and second editions of Animal Models in Cardiovascular Research emphasized normal cardiovascular parameters and the cardiovascular effects of a wide variety of drugs commonly used for restraint, anesthesia and pain control in the various animal species. The third edition is focused on the avalanche of genetic, molecular and protein-based information generated from the use of both congenic and transgenic animal models. Updated and expanded chapters provide new information generated from classical, congenic and transgenic animal models used to study ischemic heart disease, cardiomyopathy, heart failure, hypertension and atherosclerotic disease.
Completely new chapters in this third edition describe the techniques, problems and pitfalls associated with the measurement of cardiac and vascular function and ventricular/arterial coupling dynamics in various animal models. There is a new chapter detailing problems and pitfalls associated with isolated heart preparations and another describing animal models for the study of neurohumeral and CNS control of the cardiovascular system.
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