Non-Myeloablative Allogeneic Transplantation: 110 (Cancer Treatment and Research, 110) - Hardcover

Hardcover

ISBN 10: 0792376463 ISBN 13: 9780792376460

Publisher: Springer, 2002

Synopsis

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Edition details

• Publisher: Springer
• Publication date: 2002
• Language: English
• ISBN 10: 0792376463
• ISBN 13: 9780792376460
• Binding: Hardcover
• Number of pages: 226
• Editor: Bashey Asad, Ball Edward D.