Molecular Basis of Pancreas Development and Function: 11 (Endocrine Updates, 11) - Hardcover

Hardcover

ISBN 10: 0792372719 ISBN 13: 9780792372714

Publisher: Springer, 2001

Synopsis

Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.

About this title

Review

`A very interesting text for both research and clinical endocrinologists.'
Journal of Pediatric Endocrinology and Metabolism, 15:4 (2002)

Synopsis

The purpose of this book is to bring together the many different aspects of and recent discoveries in the understanding of pancreatic endocrine development and its close links to endocrine cell physiology and dysfunction in diabetes. The intention is to combine the knowledge from clinical observations in certain diabetic syndromes with the rapidly growing insights derived from basic molecular biological investigation. At the end of the book, future impacts of these studies are outlined in which the knowledge that is gained from basic studies will be translated into new forms of treatment for diabetes. It is hoped that this book will serve established investigators, newcomers to the diabetes research community, and clinicians interested in the molecular basis of the syndromes that they encounter.

Edition details

• Publisher: Springer
• Publication date: 2001
• Language: English
• ISBN 10: 0792372719
• ISBN 13: 9780792372714
• Binding: Hardcover
• Number of pages: 426
• Editor: Habener Joel F., Hussain Mehboob