This text is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the MDR genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a combination of approaches to this serious clinical problem. This book covers a wide range of topics relating to the cellular and molecular biology, as well as clinical aspects, of the problem of multiple drug resistance. Specific mechanisms discussed in detail include P-Glycoprotein and other drug transport proteins; Topoisomerases I and II; Phase I and Phase II enzymes of xenobiotic metabolism. Cellular models for MDR in solid tumours and in haemopoietic cells are discussed in detection of expression of MDR-related genes, and approaches to circumvent MDR.
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Seller: Zubal-Books, Since 1961, Cleveland, OH, U.S.A.
Condition: Very Good. *Price HAS BEEN REDUCED by 10% until Monday, June 15 (sale item)* 391 pp., Hardcover, spine cocked, else very good. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country. Seller Inventory # ZB683186
Seller: Roland Antiquariat UG haftungsbeschränkt, Weinheim, Germany
Hardcover. 1994. 391 p. Very good condition. Reading pages are clean and without markings. Out-of-print library copy with appropriate markings. Book shows slight signs of storage or use. Binding slightly stained. Otherwise a good copy. 9780792326694 Sprache: Englisch Gewicht in Gramm: 1157. Seller Inventory # 238582
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem. 391 pp. Englisch. Seller Inventory # 9780792326694
Seller: AHA-BUCH GmbH, Einbeck, Germany
Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem. Seller Inventory # 9780792326694