Histological Analysis of Endocrine Disruptive Effects in Small Laboratory Fish - Hardcover

Dietrich, Daniel; Krieger, Heiko O.

Hardcover

ISBN 10: 0471763586 ISBN 13: 9780471763581

Publisher: Wiley-Interscience, 2009

Synopsis

• Timely title assembling the combined knowledge of some of the leading authorities in the field of small fish reproduction - an important topic for risk assessment and registration of chemical, agricultural, and pharmaceutical compounds
• Provides guidance on the microscopic structure of living tissue and evaluation of the reproductive glands of small laboratory fish
• Includes state-of-the-art science along with sufficient anatomical and physiological background for understanding and interpreting test results
• Helps standardize the interpretation of results from aquatic bioassays and field observations, which will also clarify inconsistencies in the current scientific literature

Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

About this title

About the Author

Daniel R. Dietrich, PhD, is a Professor and Head of the Human and Environmental Toxicology Group, Faculty of Sciences of the University of Konstanz, Konstanz, Germany.

Heiko O. Krieger, MSc, is a scientific research assistant and PhD student in the Human and Environmental Toxicology Group, Faculty of Sciences of the University of Konstanz, Konstanz, Germany.

From the Back Cover

Standardizes the Interpretation of Results from Aquatic Bioassays and Field Observations

Although a growing number of studies employ small fish gonadal histopathology in the assessment of endocrine disrupting compounds (EDCs), the literature has lacked a comprehensive presentation of the basic biological function, the normal histology, and the histopathology of small fish gonads. In response, this book sets forth recommended standards that facilitate accurate, meaningful interpretation of the findings from aquatic bioassays and field observations of a variety of commonly studied fish species, with special emphasis on the routinely employed small laboratory fish, i.e., the zebrafish, medaka, and fathead minnow.

The authors, leaders in the field of small fish gonadal histopathology, have reviewed and synthesized more than 1,200 publications and reports to help identify and clarify inconsistencies in the field. Among the topics covered are:

• Basic fish biology and fish sexual reproduction
• Male and female fish gonad development and histopathology
• EDC-mediated effects and the relevance of parameters determined for evaluating EDC-mediated effects
• Methods for histopathological processing
• Evaluation and quantification of effects
• Experimental design and statistics

Each chapter includes references to the primary literature to facilitate further research. The appendix offers step-by-step guidance for fish preparation and microdissection of organs.

Small fish such as zebrafish, medaka, and fathead minnows are increasingly used in risk assessment studies and for the registration of chemical, agricultural, and pharmaceutical compounds. This book represents the state of the art on small fish gonadal histopathology, providing the right amount of anatomical and physiological background to help readers understand and interpret xenobiotic-induced changes in gonadal histology in a mechanistic context.

Although a growing number of studies employ small fish gonadal histopathology in the assessment of endocrine disrupting compounds (EDCs), the literature has lacked a comprehensive presentation of the basic biological function, the normal histology, and the histopathology of small fish gonads. In response, this book sets forth recommended standards that facilitate accurate, meaningful interpretation of the findings from aquatic bioassays and field observations of a variety of commonly studied fish species, with special emphasis on the routinely employed small laboratory fish, i.e., the zebrafish, medaka, and fathead minnow.

The authors, leaders in the field of small fish gonadal histopathology, have reviewed and synthesized more than 1,200 publications and reports to help identify and clarify inconsistencies in the field. Among the topics covered are:

• Basic fish biology and fish sexual reproduction
• Male and female fish gonad development and histopathology
• EDC-mediated effects and the relevance of parameters determined for evaluating EDC-mediated effects
• Methods for histopathological processing
• Evaluation and quantification of effects
• Experimental design and statistics

Each chapter includes references to the primary literature to facilitate further research. The appendix offers step-by-step guidance for fish preparation and microdissection of organs.

Small fish such as zebrafish, medaka, and fathead minnows are increasingly used in risk assessment studies and for the registration of chemical, agricultural, and pharmaceutical compounds. This book represents the state of the art on small fish gonadal histopathology, providing the right amount of anatomical and physiological background to help readers understand and interpret xenobiotic-induced changes in gonadal histology in a mechanistic context.

Edition details

• Publisher: Wiley-Interscience
• Publication date: 2009
• Language: English
• ISBN 10: 0471763586
• ISBN 13: 9780471763581
• Binding: Hardcover
• Edition number: 1
• Number of pages: 390