Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine - Hardcover

Hardcover

ISBN 10: 0470847204 ISBN 13: 9780470847206

Publisher: Wiley, 2004

Synopsis

This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders.

• Novel and potentially controversial
• Will inspire future research directions

About this title

About the Author

Robert Gerson Shulman is a biophysicist and Sterling Professor Emeritus of Molecular Biophysics and Biochemistry and a Senior Research Scientist at the Department Diagnostic Radiology at Yale University.

Douglas L. Rothman is the editor of Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine, published by Wiley.

From the Back Cover

Recent in vivo NMR studies of the brain have identified important metabolites and have measured their flows in animals and humans. 13C labeled molecules have been particularly important for these studies because the low 13C natural abundance allows labeled metabolites to stand out in NMR spectra.

Flows of labeled glucose into the glutamate, glutamine and GABA cerebral pools, measured by 13C NMR, establish the rate of glucose oxidation. In the same experiment, the rates of glutamate and GABA neurotransmitter release and recycling can be measured. Methods for performing these experiments and for interpreting the signals are described in this book, which provides the first integrated account of this rapidly growing field of functional, cerebral metabolism.

The thermodynamic relations between energy and work show that the brain efficiently uses its energy to support a high baseline level of neuronal activity in the absence of stimulation. These results lead to a proposed reformulation of fMRI experiments which have traditionally discarded the high baseline activity.

States of mind particularly, as they bear upon mental illness, have been correlated with in vivo concentrations of GABA, while the energy/neuronal firing results in epileptic patients have opened the energetic basis of this disease to study and understanding.

The quantitative, coherent picture emerging from these experiments solidifies our understanding of brain function and offers definite, novel insights into the processes of mental disorders.

Flows of labeled glucose into the glutamate, glutamine and GABA cerebral pools, measured by 13C NMR, establish the rate of glucose oxidation. In the same experiment, the rates of glutamate and GABA neurotransmitter release and recycling can be measured. Methods for performing these experiments and for interpreting the signals are described in this book, which provides the first integrated account of this rapidly growing field of functional, cerebral metabolism.

The thermodynamic relations between energy and work show that the brain efficiently uses its energy to support a high baseline level of neuronal activity in the absence of stimulation. These results lead to a proposed reformulation of fMRI experiments which have traditionally discarded the high baseline activity.

States of mind particularly, as they bear upon mental illness, have been correlated with in vivo concentrations of GABA, while the energy/neuronal firing results in epileptic patients have opened the energetic basis of this disease to study and understanding.

The quantitative, coherent picture emerging from these experiments solidifies our understanding of brain function and offers definite, novel insights into the processes of mental disorders.

Edition details

• Publisher: Wiley
• Publication date: 2004
• Language: English
• ISBN 10: 0470847204
• ISBN 13: 9780470847206
• Binding: Hardcover
• Edition number: 1
• Number of pages: 336
• Editor: Shulman Robert G., Rothman Douglas L.