Items related to Evaluation of Drug Candidates for Preclinical Development:...

Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology (Wiley Series in Drug Discovery and Development) - Hardcover

 
9780470044919: Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology (Wiley Series in Drug Discovery and Development)

Synopsis

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation

It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.

Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:

  • Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics

  • Address developability issues that challenge pharma companies, moving beyond isolated experimental results

  • Reveal connections between the key scientific areas that are critical for successful drug discovery and development

  • Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace

Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

"synopsis" may belong to another edition of this title.

About the Author

Chao Han, PHD, is Associate Director of Pharmacokinetics, Modeling and Simulation, Clinical Pharmacology Sciences, Centocor R&D. He has been working in drug discovery and early development for more than ten years, published over thirty research articles in peer-reviewed journals, and written three book chapters.

Charles B. Davis, PHD, heads Drug Metabolism and Pharmacokinetics for the cancer Metabolism Drug Discovery Unit within Cancer Research at GlaxoSmithKline. He has more than twenty years experience in preclinical and clinical development and has served on the leadership teams of three of GSK's Centers of Excellence in Drug Discovery.

Binghe Want, PHD, is Professor and Georgia research Alliance Eminent Scholar in Drug Discovery in the Department of Chemistry, Georgia State University and Georgia cancer Coalition Distinguished Scientist. He also serves as editor in chief of Medicinal research Reviews and is lead editor of Drug Delivery: Principles and Applications (Wiley).

From the Back Cover

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation

It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.

Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:

  • Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics

  • Address developability issues that challenge pharma companies, moving beyond isolated experimental results

  • Reveal connections between the key scientific areas that are critical for successful drug discovery and development

  • Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace

Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

From the Inside Flap

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation

It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.

Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:

  • Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics

  • Address developability issues that challenge pharma companies, moving beyond isolated experimental results

  • Reveal connections between the key scientific areas that are critical for successful drug discovery and development

  • Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace

Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

"About this title" may belong to another edition of this title.

Buy Used

Condition: Very Good
Hardcover issued without dust-jacket...
View this item

£ 2.25 shipping within U.S.A.

Destination, rates & speeds

Search results for Evaluation of Drug Candidates for Preclinical Development:...

Stock Image

Published by Wiley, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
Used Hardcover

Seller: Michael Knight, Bookseller, Forest Grove, OR, U.S.A.

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

hardcover. Condition: Very Good. Hardcover issued without dust-jacket. Clean and solid. Ships from a smoke-free home. Seller Inventory # mon0000013827

Contact seller

Buy Used

£ 76.79
Convert currency
Shipping: £ 2.25
Within U.S.A.
Destination, rates & speeds

Quantity: 1 available

Add to basket

Stock Image

Published by Wiley, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
New Hardcover

Seller: Romtrade Corp., STERLING HEIGHTS, MI, U.S.A.

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide. Seller Inventory # ABNR-302262

Contact seller

Buy New

£ 84.37
Convert currency
Shipping: FREE
Within U.S.A.
Destination, rates & speeds

Quantity: 1 available

Add to basket

Stock Image

Published by Wiley, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
New Hardcover

Seller: Lucky's Textbooks, Dallas, TX, U.S.A.

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

Condition: New. Seller Inventory # ABLIING23Feb2215580218534

Contact seller

Buy New

£ 104.31
Convert currency
Shipping: £ 2.99
Within U.S.A.
Destination, rates & speeds

Quantity: Over 20 available

Add to basket

Seller Image

Han, Chao (EDT); Davis, Charles B. (EDT); Wang, Binghe (EDT)
Published by Wiley, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
New Hardcover

Seller: GreatBookPrices, Columbia, MD, U.S.A.

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

Condition: New. Seller Inventory # 4150921-n

Contact seller

Buy New

£ 105.34
Convert currency
Shipping: £ 1.98
Within U.S.A.
Destination, rates & speeds

Quantity: Over 20 available

Add to basket

Stock Image

C Han
Published by Wiley-Blackwell, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
New Hardcover
Print on Demand

Seller: PBShop.store UK, Fairford, GLOS, United Kingdom

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

HRD. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # L1-9780470044919

Contact seller

Buy New

£ 105.91
Convert currency
Shipping: £ 5.02
From United Kingdom to U.S.A.
Destination, rates & speeds

Quantity: Over 20 available

Add to basket

Stock Image

Published by Wiley, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
New Hardcover

Seller: Ria Christie Collections, Uxbridge, United Kingdom

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

Condition: New. In. Seller Inventory # ria9780470044919_new

Contact seller

Buy New

£ 101.23
Convert currency
Shipping: £ 11.98
From United Kingdom to U.S.A.
Destination, rates & speeds

Quantity: Over 20 available

Add to basket

Stock Image

C Han
Published by Wiley, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
New Hardcover
Print on Demand

Seller: PBShop.store US, Wood Dale, IL, U.S.A.

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

HRD. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # L1-9780470044919

Contact seller

Buy New

£ 114.58
Convert currency
Shipping: FREE
Within U.S.A.
Destination, rates & speeds

Quantity: Over 20 available

Add to basket

Seller Image

Han, Chao (EDT); Davis, Charles B. (EDT); Wang, Binghe (EDT)
Published by Wiley, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
New Hardcover

Seller: GreatBookPricesUK, Woodford Green, United Kingdom

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

Condition: New. Seller Inventory # 4150921-n

Contact seller

Buy New

£ 101.22
Convert currency
Shipping: £ 15
From United Kingdom to U.S.A.
Destination, rates & speeds

Quantity: Over 20 available

Add to basket

Seller Image

Han, Chao (EDT); Davis, Charles B. (EDT); Wang, Binghe (EDT)
Published by Wiley, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
Used Hardcover

Seller: GreatBookPrices, Columbia, MD, U.S.A.

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

Condition: As New. Unread book in perfect condition. Seller Inventory # 4150921

Contact seller

Buy Used

£ 117.68
Convert currency
Shipping: £ 1.98
Within U.S.A.
Destination, rates & speeds

Quantity: Over 20 available

Add to basket

Stock Image

Chao Han
Published by John Wiley & Sons Inc, New York, 2010
ISBN 10: 0470044918 ISBN 13: 9780470044919
New Hardcover First Edition

Seller: Grand Eagle Retail, Bensenville, IL, U.S.A.

Seller rating 5 out of 5 stars 5-star rating, Learn more about seller ratings

Hardcover. Condition: new. Hardcover. Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most criticalpharmacokinetics and drug metabolism, pharmaceutics, and safety assessmentthis unique resource encourages integrated thinking in drug discovery. The contributors to this volume: Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics Address developability issues that challenge pharma companies, moving beyond isolated experimental results Reveal connections between the key scientific areas that are critical for successful drug discovery and development Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability. Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Seller Inventory # 9780470044919

Contact seller

Buy New

£ 125.43
Convert currency
Shipping: FREE
Within U.S.A.
Destination, rates & speeds

Quantity: 1 available

Add to basket

There are 13 more copies of this book

View all search results for this book