Successful transplantation depends on the minimization of immunological differences between the donor and recipient tissues. These differences are based on polymorphisms of the human major histocompatibility complex and play a major role in determining the acceptance or rejection of allografts during transplantation. This study describes methods for the investigation of these polymorphisms at the gene and protein levels and their application to the clinical transplanation of human organs and bone marrow.
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'a very useful book and one might safely predict that it will become a standard text on the practical aspects of histocompatibility testing'J. Andrew Bradley, Western Infirmary, Glasgow, Immunology Today, Vol. 15, No. 6, 1994
Philip Dyer, Doctor, Northwest Regional Tissue Typing Laboratory, Manchester. Derek Middleton, Doctor, Tissue Typing Laboratory, City Hospital, Belfast.
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