The Statistical Evaluation of Medical Tests for Classification and Prediction (Oxford Statistical Science Series): 31 - Softcover

Pepe, Margaret Sullivan

Softcover

ISBN 10: 0198565828 ISBN 13: 9780198565826

Publisher: Oxford University Press, 2004

Synopsis

This book describes statistical concepts and techniques for evaluating medical diagnostic tests and biomarkers for detecting disease. More generally, the techniques pertain to the statistical classification problem for predicting a dichotomous outcome. Measures for quantifying test accuracy are described including sensitivity, specificity, predictive values, diagnostic likelihood ratios and the Receiver Operating Characteristic Curve that is commonly used for continuous and ordinal valued tests. Statistical procedures are presented for estimating and comparing them. Regression frameworks for assessing factors that influence test accuracy and for comparing tests while adjusting for such factors are presented. This book presents many worked examples of real data and should be of interest to practicing statisticians or quantitative researchers involved in the development of tests for classification or prediction in medicine.

About this title

Review

Statistical results are given a methodical treatment. In each chapter statistical results are motivated, stated and usually proven, and then illustrated on a variety of datasets based on actual trials. Many of the results were developed by Pepe and her colleagues, who have advanced the field in seminal ways. Chapters end with a concluding remarks section, a set of exercises, and proofs of more involved theoretical results, when needed. Concluding remarks sections nicely summarize results and discuss open research questions. References to key papers are given throughout. This structure allows the book to serve as both a classroom text and an excellent reference to the current literature. (Journal of Biopharmaceutical Studies)

I very much recommend this book to a range of audiences, from those wanting an introduction to diagnostic test concepts and methods to active researchers in the area. This book is likely to stimulate considerable progress in development of new statistical methods for diagnostic tests, an area that relative to therapeutics has received little attention from biostatisticians. (Journal of Biopharmaceutical Studies)

About the Author

Margaret Sullivan Pepe is a Professor of Biostatistics, University of Washington; Fred Hutchinson Cancer Research Center, Washington, U.S.A. . Margaret Sullivan Pepe is a Professor of Biostatistics, University of Washington; Fred Hutchinson Cancer Research Center, Washington, U.S.A. .

Edition details

• Publisher: Oxford University Press
• Publication date: 2004
• Language: English
• ISBN 10: 0198565828
• ISBN 13: 9780198565826
• Binding: Paperback
• Number of pages: 320