Osteocalcin and type 2 diabetes mellitus

Venera Berisha-Muharremi

ISBN 10: 365995604X / ISBN 13: 9783659956041

Published by LAP LAMBERT Academic Publishing Okt 2016, 2016

About this Item

Neuware -From 2007, studies have suggested a role of undercarboxylated osteocalcin (ucOC) in glucose metabolism. The aim of the study was to investigate the relationship of ucOC level and blood glucose (BG) control in newly diagnosed type 2 diabetes (t2D) and its change with BG control improvement. Fifty seven newly diagnosed t2D patients had a consultation about life style changes on visit 1 but no BG regulation medication. The final visit (2) was after three months. BG metabolism and bone turnover parameters were measured on visit 1 and 2. Thirty two patients reached the target HbA1c (¿7%). No correlation of ucOC and HbA1c and FBG was observed. Median HbA1c and FBG changed significantly (8.0 to 6.5%; 9.0 to 7.0 mmol/L resp.; Wilcoxon signed rank test pBooks on Demand GmbH, Überseering 33, 22297 Hamburg 72 pp. Englisch.

Seller Inventory # 9783659956041

Bibliographic Details

• Title: Osteocalcin and type 2 diabetes mellitus
• Publisher: LAP LAMBERT Academic Publishing Okt 2016
• Publication Date: 2016
• Language: English
• ISBN 10: 365995604X
• ISBN 13: 9783659956041
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 5D millimeters 220 millimeters width by 150 millimeters height by 5 millimeters depth
• Weight: 125 grams
• Signed: Signed by Author(s)

About this title

Synopsis

From 2007, studies have suggested a role of undercarboxylated osteocalcin (ucOC) in glucose metabolism. The aim of the study was to investigate the relationship of ucOC level and blood glucose (BG) control in newly diagnosed type 2 diabetes (t2D) and its change with BG control improvement. Fifty seven newly diagnosed t2D patients had a consultation about life style changes on visit 1 but no BG regulation medication. The final visit (2) was after three months. BG metabolism and bone turnover parameters were measured on visit 1 and 2. Thirty two patients reached the target HbA1c (≤7%). No correlation of ucOC and HbA1c and FBG was observed. Median HbA1c and FBG changed significantly (8.0 to 6.5%; 9.0 to 7.0 mmol/L resp.; Wilcoxon signed rank test p<0.001), ucOC was slightly but not significantly lower (2.0 to 1.4 mcg/L; p=0.465). No correlation between differences in HbA1c and ucOC between Visits 1 and 2 was revealed. This study failed to prove the relationship between BG regulation and ucOC level. However, it does not exclude it, so further research is needed. The fact that as much as 56% patients achieved the target HbA1c with no medication, challenges most BG control guidelines.

About the Author

Venera Berisha-Muharremi, MD, PhD, born in 1977 in Prishtina, Kosovo, obtained PhD degree in 2014 in School of Medicine, University of Zagreb, Croatia. Currently works as a teaching assistant and as a Internal Medicine-Endocrinology specialist at the Faculty of Medicine, University of Prishtina, Kosovo. She is married and mother of two daughters.