First Edition. Hardcover. 10 1/4" X 7 1/4". xvi, 523pp. First edition, with full number line indicating first printing. Bound in glossy pictorial paper over boards. Mild rubbing and shelf wear to covers, corners, and edges of binding. Pages are clean and unmarked. Binding is firm and sound. ABOUT THIS BOOK: Learn how to conduct behavioral tests to phenotype mutant mice Dr. Jacqueline N. Crawley, author of the first and second editions of What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field hundreds of calls and e-mails from molecular geneticists who ask just that: How do I run behavioral assays to find out what's wrong with my mouse? This book answers that question and many more, including what tests are available to discover an aberrant behavioral phenotype? Turn to What's Wrong With My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the second edition up to date with the latest science. In addition, the second edition includes two new chapters: Neurodevelopment and Neurodegeneration discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. Putting It All Together recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, The Next Generation, examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor Web sites, suggestions for expert behavioral neuroscientist collaborators, and an extensive list of references, make this book a valuable and practical resource for students and researchers.(Publisher).

Seller Inventory # 13235

Contact seller

Report this item

Bibliographic Details

Title

What's Wrong With My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice (Second Edition)

Publisher

John Wiley & Sons, Inc, Hoboken

Publication Date

2007

Language

English

ISBN 10

0471471925

ISBN 13

9780471471929

Binding

Hardcover

Edition

First Edition.

Condition

Very good

Seller catalogs

Science & Nature

About this title

Synopsis

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse?

Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters:

"Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis.

"Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions.

The final chapter, "The Next Generation," examines new and emerging technologies.

Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

About the Author

Jacqueline N. Crawley, PhD, is Chief of the Laboratory of Behavioral Neuroscience at the National Institute of Mental Health; Adjunct Professor of Psychiatry and Psychology at the University of North Carolina at Chapel Hill; and Adjunct Professor of Pharmacology at Georgetown University. Dr. Crawley has published more than 200 peer-reviewed papers and 60 review articles. Her research has included rodent behavioral analyses of noradrenergic pathways; benzodiazepine receptor ligands; neuropeptide transmitters, including galanin and cholecystokinin; mouse genetic models of autism; and behavioral phenotyping of more than 30 lines of transgenic and knockout mice. Recent awards include the International Behavioral Neuroscience Society Myers Lifetime Achievement Award (2005), the Fleur Strand Summer Neuropeptide Conference Award (2005), the Howard Hughes Medical Institute Preceptor Award (2004), and the National Institute of Mental Health Director's Award (2002).

What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice, Second Edition has been written in Dr. Crawley's private capacity, outside of her professional position at the National Institutes of Health. The views expressed in this book do not necessarily represent the views of the National Institutes of Health or of the United States government.

"About this title" may belong to another edition of this title.

Store Description

Underground Books, ABAA is an online rare and antiquarian bookshop, founded in 2011 as a brick and mortar general bookstore of the same name in downtown Carrollton, Georgia, which is now operated by out former store manager as The Underground Bookshop. Co-owners Josh Niesse and Megan Bell met in 2011, just 10 days or so after Josh opened the doors of Underground Books, literally underground, several steps below street level in a 100-year-old basement in our historic downtown. Megan, an English student at the University of West Georgia, walked in, fell down the rabbit hole, and never left! Reader, we married in May of 2014, under the book arch that now resides at the bookshop. We are both proud alumni of the Colorado Antiquarian Book Seminar (CABS), and Megan additionally of Rare Book School at the University of Virginia and of the ABAA Women?s Initiative Mentorship Program. Like many booksellers with open brick-and-mortar stores, we are passionate generalists, but our specialties are in decorative publisher's cloth bindings; fairy tales, folklore, and mythology; popular science and natural history; the occult; and fine press books.

Visit Seller's Storefront

Association Member

Members of these associations are committed to maintaining the highest standards. They vouch for the authenticity of all items offered for sale. They provide expert and detailed descriptions, disclose all significant defects and/or restorations, provide clear and accurate pricing, and operate with fairness and honesty during the purchase experience.

Seller's business information

Underground Books, ABAA
GA, U.S.A.

Sale & Shipping Terms

Terms of Sale

We guarantee the condition of every book as it's described on the Abebooks web sites. If you're dissatisfied with your purchase (Incorrect Book/Not as Described/Damaged) or if the order hasn't arrived, you're eligible for a refund within 30 days of the estimated delivery date. If you've changed your mind about a book that you've ordered, please use the Ask bookseller a question link to contact us and we'll respond promptly. If you are not satisfied for any reason you may return your book for a f...

More Information

Right of withdrawal

If you are a consumer you can withdraw from the contract in accordance with the following. Consumer means any natural person who is acting for purposes which are outside his trade, business, craft or profession.

Information regarding the right of withdrawal

Statutory right to withdraw

You have the right to withdraw from this contract within 14 days without giving any reason.

The withdrawal period will expire after 14 days from the day on which you acquire, or a third party other than the carrier and indicated by you acquires, physical possession of the last good or the last lot or piece.

To exercise the right of withdrawal, electronically fill in and submit a clear statement on our website, under "My Purchases" in "My Account". We will communicate to you an acknowledgement of receipt of such a withdrawal on a durable medium (e.g. by e-mail) without delay.

To meet the withdrawal deadline, it is sufficient for you to send your communication concerning your exercise of the right of withdrawal before the withdrawal period has expired.

Effects of withdrawal

If you withdraw from this contract, we will reimburse to you all payments received from you, including the costs of delivery (except for the supplementary costs arising if you chose a type of delivery other than the least expensive type of standard delivery offered by us).

We may make a deduction from the reimbursement for loss in value of any goods supplied, if the loss is the result of unnecessary handling by you.

We will make the reimbursement without undue delay, and not later than 14 days after the day on which we are informed about your decision to withdraw from this contract.

We will make the reimbursement using the same means of payment as you used for the initial transaction, unless you have expressly agreed otherwise; in any event, you will not incur any fees as a result of such reimbursement.

We may withhold reimbursement until we have received the goods back, or you have supplied evidence of having sent back the goods, whichever is the earliest.

You shall send back the goods or hand them over to Underground Books, ABAA, Carrollton, Georgia, U.S.A., without undue delay and in any event not later than 14 days from the day on which you communicate your withdrawal from this contract to us. The deadline is met if you send back the goods before the period of 14 days has expired. You will have to bear the direct cost of returning the goods. You are only liable for any diminished value of the goods resulting from the handling other than what is necessary to establish the nature, characteristics and functioning of the goods.

Exceptions to the right of withdrawal

The right of withdrawal does not apply to:

The delivery of newspapers, journals or magazines with the exception of subscription contracts; and
The supply of digital content which is not supplied on a tangible medium (e.g. on a CD or DVD) if you accepted when you placed your order that we could start to deliver it, and that you could not withdraw once delivery had started.

Shipping Terms

Orders will ship within 2 business days. Shipping costs are based on books weighing 2.2 LB, or 1 KG. If your book order is heavy or oversized, we may contact you to let you know extra shipping is required. If you are not satisfied for any reason you may return your book for a full refund, and if the error is ours, we will pay return shipping.

Shipping rates within U.S.A.

Shipping rates within U.S.A.
Order quantity	3 to 14 business days	2 to 6 business days
First item	� 4.17	� 8.14

Delivery times are set by sellers and vary by carrier and location. Orders passing through Customs may face delays and buyers are responsible for any associated duties or fees. Sellers may contact you regarding additional charges to cover any increased costs to ship your items.