Tumor Suppressor Par-4 (Hardcover)
Language: English
Published by Springer Nature Switzerland AG, Cham, 2021
- First Edition
- Hardcover
- New
Seller: Grand Eagle Retail, Bensenville, IL, U.S.A.Grand Eagle Retail
AbeBooks seller since October 12, 2005
Condition: New
£ 192.97
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Hardcover. Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimers and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials.This second, companion volume will provide a comprehensive overview of Par-4s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…
Seller Inventory # 9783030805579
- Title
- Tumor Suppressor Par-4 (Hardcover)
- Author
- Vivek M. Rangnekar
- Publisher
- Springer Nature Switzerland AG, Cham
- Publication year
- 2021
- Condition
- new
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 3030805573
- ISBN 13
- 9783030805579
- Edition
- 1st Edition
This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.
"Synopsis" may belong to another edition of this title.
About the Author
"About the title" may belong to another edition of this title.
Grand Eagle Retail
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