Protein Surface Recognition (Hardcover)

Ernest Giralt

ISBN 10: 0470059052 / ISBN 13: 9780470059050

Published by John Wiley & Sons Inc, New York, 2010

About this Item

Hardcover. A new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key cellular processes related to human disease. Protein Surface Recognition presents a detailed treatment of this strategy, with topics including: an extended survey of protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspectivethe fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfacesexamples of protein surface-small molecule interactions, including treatments of protein-natural product interactions, protein-interface peptides, and rational approaches to protein surface recognition from model to biological systemsa survey of techniques that will be integral to the discovery of new small molecule protein surface binders, from high throughput synthesis and screening techniques to in silico and in vitro methods for the discovery of novel protein ligands. Protein Surface Recognition provides an intellectual tool-kit for investigators in medicinal and bioorganic chemistry looking to exploit this emerging paradigm in drug discovery. A new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein/protein interactions. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.

Seller Inventory # 9780470059050

Bibliographic Details

• Title: Protein Surface Recognition (Hardcover)
• Publisher: John Wiley & Sons Inc, New York
• Publication Date: 2010
• Language: English
• ISBN 10: 0470059052
• ISBN 13: 9780470059050
• Binding: Hardcover
• Edition: 1st Edition
• Condition: new

About this title

Synopsis

A new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key cellular processes related to human disease.

Protein Surface Recognition presents a detailed treatment of this strategy, with topics including:

• an extended survey of protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspective
• the fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfaces
• examples of protein surface-small molecule interactions, including treatments of protein-natural product interactions, protein-interface peptides, and rational approaches to protein surface recognition from model to biological systems
• a survey of techniques that will be integral to the discovery of new small molecule protein surface binders, from high throughput synthesis and screening techniques to in silico and in vitro methods for the discovery of novel protein ligands.

Protein Surface Recognition provides an intellectual “tool-kit” for investigators in medicinal and bioorganic chemistry looking to exploit this emerging paradigm in drug discovery.

About the Author

ERNEST GIRALT, Department of Organic Chemistry, University of Barcelona and Institute for Research in Biomedicine, Barcelona, Spain

MARK PECZUH, Department of Chemistry, University of Connecticut, USA

XAVIER SALVATELLA, ICREA and Institute for Research in Biomedicine, Barcelona, Spain