Neuromodulation, Vol. 1

Volume 1. Oversized cloth hardcover, weight: 1.88kg, xxiii + 526 pages, illustrated in full colour, NOT ex-library. Minor signs of gentle handling only. Book is clean and bright throughout with unmarked text, free of inscriptions and stamps, firmly bound. Dust jacket shows shelfwear and a few scratches. -- Contents: Section 1: An Introduction to Neuromodulation -- What Is Neuromodulation?; Neuromodulation: A Historical Perspective; Neuromodulation Technologies: Whom Do We Serve?; Challenges in Moving Toward Product Development; Birth of an Industry; Beginnings of the Societies; Clinical Study Design; Psychological Issues and Evaluation for Patients Undergoing Implantable Technology; Deep Brain Stimulation: Ethical Issues in Clinical Practice and Neurosurgical Research; -- Section 2: Fundamentals of Neuromodulation -- Introduction; Anatomy of the Nervous System; Fundamentals of Electrical Stimulation; Neuromodulation and Neuronal Plasticity; Gene-Based Neuromodulation; -- Section 2a Mechanisms -- Principles of Electric Field Generation for Stimulation of the Central Nervous System; Mechanisms of Action of Deep Brain Stimulation: A Review; Computational Modeling of Deep Brain Stimulation; -- Section 3: Biomedical Engineering Considerations -- Introduction; Electrodes for the Neural Interface; Implantable Neural Stimulators; Designing a Neural Interface System to Restore Mobility; MRI Safety and Neuromodulation Systems; -- Section 4: Neuromodulation for Chronic Pain -- Introduction; Physiology and Pathophysiology of Chronic Pain; Endogenous Neuromodulation System; Management Strategies for Chronic Pain; -- Section 4A Periphery and Spinal Cord Electrical Stimulation for Non-Visceral Pain -- Transcutaneous Electrical Nerve Stimulation (TENS): A Review; Mechanisms of Spinal Cord Stimulation in Neuropathic and Ischemic Pain Syndromes; Cost-Effectiveness of Spinal Cord Stimulation; Spinal Cord Stimulation for Painful Neuropathies; Neurostimulation in the Treatment of Complex Regional Pain Syndrome; Peripheral Nerve Stimulation for Pain Peripheral Neuralgia and Complex Regional Pain Syndrome; Occipital Neurostimulation for Treatment of Intractable Headache Syndromes; Subcutaneous Targeted Stimulation; -- Section 4B Infusional Therapies for Pain -- Relevant Anatomy for Spinal Delivery; Rational Use of Intrathecal Opioid Analgesics; Intrathecal Analgesics, Choice of System; Intrathecal Non-Opioid Analgesics for the Control of Pain; Compounding Intrathecal Drugs; Intracerebroventricular Opioid Administration for Chronic Pain; -- Section 4C Brain Stimulation for Pain -- Deep Brain Stimulation for Pain; Deep Brain Stimulation of the Posterior Hypothalamus in Chronic Cluster Headache; Motor Cortex Stimulation for the Treatment of Neuropathic Pain -- Neuromodulation devices and treatments are life changing. Electrical or biochemical stimulation of organs via implanted devices promises new treatment opportunities for a large number of diseases or symptoms from headaches to tremors to spinal cord damage to urinary incontinence. With such a broad therapeutic scope, and significant ongoing improvements in biotechnology, it is not surprising that neuromodulation is poised as a major growth industry for the next decade. Treatments with neuromodulation have already been applied successfully in chronic pain relief, deep brain stimulation (DBS) treatment for Parkinson's disease, sacral nerve stimulation for pelvic disorders and incontinence, spinal cord stimulation for ischemic disorders (angina, peripheral vascular disease), and more. "Neuromodulation" is the first comprehensive and in-depth reference textbook to cover all aspects of the field including fundamentals of neuromodulation, bioengineering considerations, and clinical uses.