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4 leaves, 88 pp; 1 plate. With red and black title page and engraved vignette on title page. Contemporary addition in ink on p. 88, which is the legend for "M" on the plate. I have seen this manuscript note on three other copies and may be in all copies. Recent vellum. Covers warped. Foxed throughout. Untrimmed. First Edition. The first edition is very uncommon, and should not be confused with the several later editions. Garrison-Morton 1382. Cotugno "was the first to describe the fluid surrounding the spinal cord and to suggest that it was in continuity with the ventricular and cerebral subarachnoid fluids. However, his concept of the cerebral and spinal fluid, which is the beginning of its modern physiology, remained in obscurity until rediscovery by Magendie some 60 years later" (Clarke & O'Malley, Human Brain and Spinal Cord, pp. 721-2; see also pp. 728-31). Haymaker & Schiller, Founders of Neurology, pp. 19-22. Garrison's History of Neurology, p. 99. Spillane, Doctrine of the Nerves, pp. 122-23. Garrison-Morton 4515: "Cotugno published a classic description of sciatica, which is useful even today. He recognized two types--arthritic and nervous; the latter has been called 'Cotugno's disease', and his book is confined to that type. The book . . . also describes a case of acute nephritis." Garrison-Morton 4204.2: "This classic work on sciatica includes the first clear descripiton of the association of oedema with proteinuria." Norman 522. LeFanu, Notable Medical Books from the Lilly Library, p. 129. OCLC locates copies of the scarce first edition in these US libraries: Harvard, Illinois (Chicago), Iowa, National Library of Medicine, North Carolina. OCLC also locates five copies in libraries outside the US: 2 in Canada, 1 in England, 1 in Germany, and 1 in Sweden.
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