Initial sequencing and comparative analysis of the mouse genome. (With several related articles), pp. 520-562 in: Nature, vol. 420, no. 6915, 5 December 2002. SEQUENCING THE MOUSE GENOME
Published by London: Nature Publishing Group, 2002
- First Edition
- Softcover
- Used
Seller: Landmarks of Science Books, Richmond, United KingdomLandmarks of Science Books
AbeBooks seller since March 17, 2016
Condition: Used - Near fine
£ 150.00
Quantity: 1 available
Add to basketItem description from seller
First edition, complete journal issue in original printed wrappers, of the first announcement of the sequencing of the mouse genome - the genetic blueprint of a mouse - together with a comparative analysis of the mouse and human genomes describing insights gleaned from the two sequences. "The achievement represents a landmark advance for the Human Genome Project. It is the first time that scientists have compared and contrasted the contents of the human genome with that of another mammal. This milestone is all the more significant given that the laboratory mouse is the most important animal model and is widely used in the study of human diseases . . . The mouse sequence provides scientists a powerful research tool to extract meaning from the human genome sequence, the "Book of Life" published in draft form last year. It allows them to recognize functionally important regions in the human genome by virtue of the fact that they are conserved through the 75 million years of evolution separating humans and mice. 'This is an extraordinary milestone. For the first time we have an opportunity to see ourselves in an evolutionary mirror,' says Eric Lander, Ph.D., director of the Whitehead/MIT Center for Genome Research. 'The mouse genome represents a very important chapter in evolution's lab notebook. Being able to read this notebook and compare genomic information across species allows us to glean important information about ourselves.' Because the mouse carries virtually the same set of genes as the human but can be used in laboratory research, this information will allow scientists to experimentally test and learn more about the function of human genes, leading to better understanding of human disease and improved treatments and cures . . . The sequence shows the order of the DNA chemical bases A, T, C, and G along the 20 chromosomes of a female mouse of the 'Black 6' strain - the most commonly used mouse in biomedical research. It includes more than 96 percent of the mouse genome with long, continuous stretches of DNA sequence and represents a seven-fold coverage of the genome. This means that the location of every base, or DNA letter, in the mouse genome was determined an average of seven times, a frequency that ensures a high degree of accuracy . . . Comparison of human and mouse genomes - some highlights: The mouse genome is composed of 2.5 billion bases. This is about 14 percent shorter than the human genome. The human genome has more repeated DNA sequences than does the mouse genome; Although mice and humans are separated by 75 million years of evolution, 90 percent of the mouse genome can be aligned with large segments of chromosomes in the human genome; The number of genes estimated to be in the mouse genome was about 30,000. This is similar to the number estimated to be in the human genome. As with humans, this number was later lowered to the 20,000-25,000 range" (National Human Genome Research Institute). Large 8vo, pp. xxxviii, 447-590, [6], 56, with large foldout genome map loosely inserted. Original printed wrappers (very minor wear to extremities).…
Seller Inventory # ABE-1619000750934
Bibliographic details
- Title
- Initial sequencing and comparative analysis of the mouse genome. (With several related articles), pp. 520-562 in: Nature, vol. 420, no. 6915, 5 December 2002. SEQUENCING THE MOUSE GENOME
- Author
- Waterson, R.H., Lindblad-Toh, K., Birney, E,. Rogers, J., et al.
- Publisher
- London: Nature Publishing Group
- Publication year
- 2002
- Condition
- Near Fine
- Binding
- Soft cover
- Edition
- 1st Edition
Landmarks of Science Books
Richmond, United Kingdom
AbeBooks seller since March 17, 2016
Shipping rates from United Kingdom to U.S.A.
| Item | 14 to 45 business days | 5 to 10 business days |
|---|---|---|
| First item | £ 30.00 | £ 50.00 |
Payment methods
- Bank Draft
- Bank Wire Transfer
- Check
- Paypal
Specialty
Antiquarian Science and MedicineSeller's business information
Dinglecom Ltd
266 Belsize Road
London, United Kingdom NW6 4BT
Terms of sale
Company details:
Dinglecom Ltd
266 Belsize Road
London
NW6 4BT
UK
Authorized representative:
Andrew Pressley
Consumer complaints should be addressed to:
Andrew Pressley
17 King George Square
Richmond
TW10 6LF
UK
Right of withdrawal
If you are a consumer you can withdraw from the contract in accordance with the following. Consumer means any natural person who is acting for purposes which are outside his trade, business, craft or profession.
Information regarding the right of withdrawal
Statutory right to withdraw
You have the right to withdraw from this contract within 14 days without giving any reason.
The withdrawal period will expire after 14 days from the day on which you acquire, or a third party other than the carrier and indicated by you acquires, physical possession of the last good or the last lot or piece.
To exercise the right of withdrawal, electronically fill in and submit a clear statement on our website, under "My Purchases" in "My Account". We will communicate to you an acknowledgement of receipt of such a withdrawal on a durable medium (e.g. by e-mail) without delay.
To meet the withdrawal deadline, it is sufficient for you to send your communication concerning your exercise of the right of withdrawal before the withdrawal period has expired.
Effects of withdrawal
If you withdraw from this contract, we will reimburse to you all payments received from you, including the costs of delivery (except for the supplementary costs arising if you chose a type of delivery other than the least expensive type of standard delivery offered by us).
We may make a deduction from the reimbursement for loss in value of any goods supplied, if the loss is the result of unnecessary handling by you.
We will make the reimbursement without undue delay, and not later than 14 days after the day on which we are informed about your decision to withdraw from this contract.
We will make the reimbursement using the same means of payment as you used for the initial transaction, unless you have expressly agreed otherwise; in any event, you will not incur any fees as a result of such reimbursement.
We may withhold reimbursement until we have received the goods back, or you have supplied evidence of having sent back the goods, whichever is the earliest.
You shall send back the goods or hand them over to Landmarks of Science Books, Richmond, United Kingdom, without undue delay and in any event not later than 14 days from the day on which you communicate your withdrawal from this contract to us. The deadline is met if you send back the goods before the period of 14 days has expired. You will have to bear the direct cost of returning the goods. You are only liable for any diminished value of the goods resulting from the handling other than what is necessary to establish the nature, characteristics and functioning of the goods.
Exceptions to the right of withdrawal
The right of withdrawal does not apply to:
- The delivery of newspapers, journals or magazines with the exception of subscription contracts; and
- The supply of digital content which is not supplied on a tangible medium (e.g. on a CD or DVD) if you accepted when you placed your order that we could start to deliver it, and that you could not withdraw once delivery had started.