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1 fascicule in-8 (21.5 x 14 cm), paginé 210-216, broché, couverture muette moderne (papier vergé bleu), quelques rousseurs, bon état. Edition originale rare. La "lecture" fondamentale de Villemin occupe la plus grande partie de cette brochure, plus précisément 4 page ½ (pp. 211-216). Il s'agit de la première communication de Villemin sur le sujet, faisant date dans l'histoire de la médecine. Villemin démontre de façon irréfutable, par expérimentation animale (lapin), l'inoculabilité, la transmissibilité et la spécificité de la tuberculose (vingt ans avant la découverte par Koch de son agent pathogène). Cette première communication, révolutionnaire, fut accueilli par une incrédulité générale. L'importance et le caractère novateur de ces conclusions conduisirent l'Académie de médecine à nommer une commission, qui vérifia et confirma les résultats de l'auteur. Villemin fit plusieurs communications et rédigea un important ouvrage en 1868, avant de convaincre la communauté scientifique internationale. Jean Antoine Villemin (1827-1892) fut médecin militaire à Strasbourg, puis au Val-de-Grâce, où il fut professeur d'hygiène et de médecine légale, puis de clinique médicale. Il devint en 1885 médecin inspecteur de l'armée. Il fut élu membre de l'Académie de médecine. REFERENCES: Bloomfield AL: A bibliography of internal medicine, Communicable diseases, pp. 207-208: "From long study of the clinical and pathological features of tuberculosis, Villemin became convinced that 'tuberculosis is the result of a specific causal agent, in other words a virus'. He then presented proof that this was the true by a series of precise experiments. This work was so epoch-making that we shall quote in detail from one of the many observations."; Barberis I et al.: The history of tuberculosis: from the first historical records to the isolation of Koch's bacillus, J Prev Med Hyg. 2017 Mar; 58(1): E9?E12: "The infectious nature of TB was demonstrated in 1865 by Jean-Antoine Villemin, a French military surgeon at the Army Medical School. He formulated his hypothesis observing that TB was more frequent among soldiers who stationed for long times in barracks than among those in the field. He also highlighted how healthy army recruits coming from the countryside often became consumptive some months after the beginning of their service. Villemin's experiments consisted in inoculating a rabbit with 'a small amount of purulent liquid from a tuberculous cavity' removed at autopsy from an individual died of TB. As described in Villemin's work Cause et nature de la tuberculose: son inoculation de l'homme au lapin, the inoculated animal remained alive and no disease signs were discovered, but at autopsy, three months later, extensive TB was evident."; Cambau E & Drancourt M: Steps towards the discovery of Mycobacterium tuberculosis by Robert Koch, 1882, Clin Microbiol Infect. 2014 Mar;20(3):196-201: "Interestingly, the first sentence of the seminal paper by Koch acknowledges previous work by Jean-Antoine Villemin (1827?1892), a French army doctor, who first demonstrated the transmissibility of tuberculosis."; Daniel TM: The history of tuberculosis, Respir Med. 2006, 100(11), 1862-70: "Understanding of the pathogenesis of tuberculosis began with the work of Théophile Laennec at the beginning of the 19th century and was further advanced by the demonstration of the transmissibility of Mycobacterium tuberculosis infection by Jean-Antoine Villemin and the identification of the tubercle bacillus as the etiologic agent by Robert Koch in 1882.". Seller Inventory # 1407-3
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