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PF. Condition: New.
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The Future of Predictive Safety Evaluation: In Two Volumes Volumes 2
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Seller rating 5 out of 5 stars
£ 50.43
£ 11.98 shipping
Ships from United Kingdom to U.S.A.Quantity: Over 20 available
Add to basketCondition: New. In.
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The Future of Predictive Safety Evaluation: In Two Volumes Volume 1
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Seller rating 5 out of 5 stars
£ 50.43
£ 11.98 shipping
Ships from United Kingdom to U.S.A.Quantity: Over 20 available
Add to basketCondition: New. In.
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Paperback. Condition: New.
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Condition: New. pp. 240.
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Condition: New. pp. 324.
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The Future of Predictive Safety Evaluation : In Two Volumes Volume 2
Language: English
Published by Dordrecht : Springer Netherlands, 1987
ISBN 10: 9400932014 ISBN 13: 9789400932012
Seller: Roland Antiquariat UG haftungsbeschränkt, Weinheim, Germany
Seller rating 5 out of 5 stars
Hardcover. 312 p. Good condition. Reading pages are clean and without marks. Retired library exemplar with library markings. Slight traces of storage or usage. Cover yellowed. Otherwise very good exemplar. 9789400932012 Sprache: Englisch Gewicht in Gramm: 1000.
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The Future of Predictive Safety Evaluation: In Two Volumes Volume 1
Language: English
Published by Springer Netherlands, 2013
ISBN 10: 9401083363 ISBN 13: 9789401083362
Paperback. Condition: Brand New. 240 pages. 9.25x6.10x0.55 inches. In Stock.
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Paperback. Condition: Brand New. 324 pages. 9.25x6.10x0.73 inches. In Stock.
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Hardcover. Condition: Very Good.
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The Future of Predictive Safety Evaluation
Language: English
Published by Springer Netherlands, 2011
ISBN 10: 9401083363 ISBN 13: 9789401083362
Condition: New. A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means . can give rise to toxicity in animals and human beings, and that they must be sub.
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Taschenbuch. Condition: Neu. The Future of Predictive Safety Evaluation | In Two Volumes Volumes 2 | A. N. Worden (u. a.) | Taschenbuch | 320 S. | Englisch | 2011 | Springer | EAN 9789401079365 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
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The Future of Predictive Safety Evaluation : In Two Volumes Volumes 2
Language: English
Published by Springer, Springer Netherlands, 2011
ISBN 10: 9401079366 ISBN 13: 9789401079365
Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.
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Taschenbuch. Condition: Neu. Neuware - A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means . can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that 'All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison', and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity.
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Condition: new. Questo è un articolo print on demand.
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The Future of Predictive Safety Evaluation
Language: English
Published by Springer Netherlands Dez 2011, 2011
ISBN 10: 9401079366 ISBN 13: 9789401079365
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens. 324 pp. Englisch.
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Condition: New. Print on Demand pp. 240 Illus.
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Condition: New. Print on Demand pp. 324 49:B&W 6.14 x 9.21 in or 234 x 156 mm (Royal 8vo) Perfect Bound on White w/Gloss Lam.
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Condition: New. PRINT ON DEMAND pp. 240.
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Condition: New. PRINT ON DEMAND pp. 324.
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The Future of Predictive Safety Evaluation
Language: English
Published by Springer Netherlands, 2011
ISBN 10: 9401079366 ISBN 13: 9789401079365
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive pot.
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The Future of Predictive Safety Evaluation
Language: English
Published by Springer, Springer Netherlands Dez 2011, 2011
ISBN 10: 9401079366 ISBN 13: 9789401079365
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
Seller rating 5 out of 5 stars
Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 324 pp. Englisch.
