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Published by LAP LAMBERT Academic Publishing, 2021
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Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Sharma Dinesh KumarMr. Dinesh Kumar Sharma working as an Assistant Professor at Centurion University of Technology and Management, Odisha, India. His prime research area included Novel Drug Delivery System, Targeted Drug Delivery Sys.
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Published by LAP LAMBERT Academic Publishing, 2021
ISBN 10: 620341087X ISBN 13: 9786203410877
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Published by LAP LAMBERT Academic Publishing, 2021
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.
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Published by LAP LAMBERT Academic Publishing Feb 2021, 2021
ISBN 10: 620341087X ISBN 13: 9786203410877
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 108 pp. Englisch.
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Published by LAP LAMBERT Academic Publishing, 2021
ISBN 10: 620341087X ISBN 13: 9786203410877
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Taschenbuch. Condition: Neu. Formulation and Development of Bilayer Floating Tablets of Nifedipine | Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique | Dinesh Kumar Sharma (u. a.) | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2021 | LAP LAMBERT Academic Publishing | EAN 9786203410877 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu Print on Demand.