Serres Frederick (115 results)

Condition: Good. Former library book; may include library markings. Used book that is in clean, average condition without any missing pages.

Condition: Good. *Price HAS BEEN REDUCED by 10% until Monday, Jan. 26 (weekend SALE item)* 348 pp., hardcover, ex library, else text clean & binding tight. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country.

Condition: Very Good. Very Good condition. Volume 38. A copy that may have a few cosmetic defects. May also contain light spine creasing or a few markings such as an owner's name, short gifter's inscription or light stamp. Bundled media such as CDs, DVDs, floppy disks or access codes may not be included.

Condition: Good. Volume 9. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,650grams, ISBN:0306416964.

Condition: Good. Volume 8. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,800grams, ISBN:0306413361.

Hardcover. Condition: Fine. Octavo in brown cloth, gilt text on spine; illus.; 348 pp., 24 cm. Environmental Mutagen Society; In English; Contents: Includes the text of the Toxic Substances Control Act of 1976; from the library of Nobel laureate Dr. Donald A. Glaser, inventor of the bubble chamber with his UC Berkeley name and department stamp to ffep; search keyword DGLSR for more titles from the extensive Glaser library. Fine copy; Dr. Glaser's personal library spine label at spine tail; o/w cloth is clean; pages are clean, crisp, bright and free of marks and creases; edges of leaves are clean; binding is tight and square; a well-cared-for copy.

Hardcover. Condition: Very Good+. Dust Jacket Condition: Very Good. 348pp.incl.index; HB brwn.w/gilt; slight rub w/clean,tight pgs. DJ green w/white; rubbed w/wear; chips&tears. " .designed to encourage the development and application of testing and monitoring procedures to avert human exposure to mutagenic agents.".

Hardcover. 289pp. Slight shelfwear, stamp on front endpaper, else very good condition with text clean & binding tight w/o dust jacket.

Hardcover. Condition: Fine. Dust Jacket Condition: Very Good. hardback in near fine condition with very good dust jacket.

Condition: Good. *Price HAS BEEN REDUCED by 10% until Monday, Jan. 26 (weekend SALE item)* 485 pp., hardcover, ex library, else text and binding clean and tight in good dust jacket. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country.

Hardcover. Condition: Fine. Octavo in brown cloth, brown text on spine; illus.; 304 pp., 24 cm. In English. Environmental Mutagen Society; from the library of Nobel laureate, Dr. Donald A. Glaser, inventor of the bubble chamber with his UC Berkeley name and address stamp to ffep; search keyword DGLSR for more collectible titles from the extensive Glaser collection. Fine copy; Dr. Glaser's personal library spine label at spine tail; o/w cloth is clean; pages are clean, crisp, bright and free of marks and creases; edges of leaves are clean; binding is tight and square; a well-cared-for copy.

Hardcover. Condition: UsedGood. Hardcover; surplus library copy with the usual stampings; reference number written on spine; fading and shelf wear to exterior; fade spots to page edges; in good condition with clean text, firm binding. No dust jacket.

Hardcover. Condition: Fine. Octavo in brown cloth, gilt text on spine; illus.; 364 pp., 24 cm. In English. Environmental Mutagen Society; from the library of Nobel laureate, Dr. Donald A. Glaser, inventor of the bubble chamber with his UC Berkeley name and address stamp to ffep; search keyword DGLSR for more collectible titles from the extensive Glaser collection. Fine copy; Dr. Glaser's personal library spine label at spine tail; o/w cloth is clean; pages are clean, crisp, bright and free of marks and creases; edges of leaves are clean; binding is tight and square; a well-cared-for copy.

Condition: New.

Condition: New.

Condition: New.

Condition: New.

Hardcover. Condition: Fine. Octavo in brown cloth, brown text on spine; illus.; pages 311-610, 24 cm. In English; from the library of Nobel laureate Dr. Donald A. Glaser, inventor of the bubble chamber; search keyword DGLSR for more collectible titles from the extensive Glaser library; volume 2 of 2. Fine copy with Dr. Glaser's private library spine label on spine tail; o/w cloth is clean; boards are free of bumps; pages are clean, crisp, bright and free of marks and creases; edges of leaves are clean; binding is tight and square; a well-cared-for copy.

and platns on the biosatellite II and gemini XI missions (S. A. Life Sci. and Speace Res. VII) 1969. S. 62 - 66. (St.) br. -2) Sonderabdruck.

V. Evidence for allelic complementation among ad-3B mutants (S. A. Genetics 48) 1963. S. 351 - 360. m. zahlr. Abb. br. -2/3) Sonderabdruck.

Paperback. Condition: new. Paperback. The study of the relationship between environmental pollution and human health is in its infancy. The number of substances and mixtures that have been identified in uncontrolled hazardous waste sites or that have been in advertently released into the environment is large and data on how thes~ substances are modified as they interact with one another as they migrate through soil, air, and water are limited. There are also limits on our un derstanding of how these substances may be ingested, inhaled, or absorbed by people. The complexity of possible interactions between biological, chemical, and physical components in a given environment makes it virtually impossible to evaluate the potential for adverse biological effects ade quately in the laboratory. Other, more comprehensive methods which provide realistic and interpretable results must be used. Many scientists believe that humans represent the ultimate sentinel species of a toxic exposure re sUlting from environmental pollution, however such exposures may also se verely impact environmental health. There exists a wide variety of organ isms in the natural environment that could be used to provide an early warning for potential human health effects as well as to indicate adverse ecological effects. The issue of effective utilization of sentinel species for environment al monitoring is a rapidly developing area of research which has grown in importance during the last decade. There exists a wide variety of organ isms in the natural environment that could be used to provide an early warning for potential human health effects as well as to indicate adverse ecological effects. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Paperback. Condition: new. Paperback. As a result of the industrial revolution, man's technological achievements have been truly great, increasing the quality of life to almost unimagined proportions; but all this progress has not been accomplished without equally un imagined health risks. Sufficiently diagnostic short-term assay procedures have been developed in recent years for us to determine that there are mutagenic agents among thou sands of chemicals to which the human population is exposed today. These chemicals were not significantly present prior to the indus trial revolution. As of today, there are no procedures available which have been adequately demonstrated to assess individual sus ceptibility to genotoxic exposures, and as a result we have had to rely on extrapolating toxicological data from animal model systems. The question is can we afford to allow such an increased environ mental selection pressure via mutagenic exposures to occur without expecting adverse long-term effects on our health. It is apparent from this line of reasoning that what is lacking and immediately needed are test procedures that can be applied to humans to assess genotoxic exposure as well as individual susceptibility to it. There have already been two conferences which have focused at tention on this research area. "Guidelines for studies of human populations exposed to mutagenic and reproductive hazards" (A. D. Bloom, ed., March of Dimes Birth Defects Foundation, White Plains, New York, 1981) and "Indicators of genotoxic exposure in humans" (Banbury Report 13, B. A. Bridges, B. E. Butterworth, and I. B. Bloom, ed., March of Dimes Birth Defects Foundation, White Plains, New York, 1981) and "Indicators of genotoxic exposure in humans" (Banbury Report 13, B. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Paperback. Condition: new. Paperback. Volume 9 of Chemical Mutagens consists mainly of chapters discussing the development and validation of short-term assays to detect the mutagenic effects of environmental chemicals. These chapters include an assay with the grasshopper neuroblast, a comparison of mutagenic responses of human lung-derived and skin-derived diploid fibroblasts, a forward-mutation assay in Salmonella, a multigene sporulation test in Bacillus subtilis, a specific locus assay in mouse lymphoma cells, a study of the induction of bacteriophage lambda, and the granuloma pouch assay. In addition, there are two chapters on the identification of mutagens in cooked food and in human feces. Frederick 1. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 The Grasshopper Neuroblast Short-Term Assay for Evaluating the Effects of Environmental Chemicals on Chromosomes and Cell Kinetics 1 Mary Esther Gaulden, Jan C. Liang, and Martha J. Ferguson 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Embryo Supply. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 1. Species. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 2. Origin of Colonies . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 3. Life Cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 4. Colony Maintenance . . . . . . . . . . . . . . . . . . . . . . . . . 6 2. 5. Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2. 6. Allergy to Grasshoppers . . . . . . . . . . . . . . . . . . . . . . 14 3. Grasshopper Egg, Embryo, and Cells . . . . . . . . . . . . . . . . . 14 3. 1. The Egg Shell and Membranes . . . . . . . . . . . . . . . . . 14 3. 2. Embryonic Development . . . . . . . . . . . . . . . . . . . . . 17 3. 3. Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 4. Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 1. Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 2. Preparation of Embryos for Cell Analysis . . . . . . . . . 34 4. 3. Analysis of Mutagen Effects. . . . . . . . . . . . . . . . . 40 . . . 5. Response of the Grasshopper Neuroblast to Mutagens . . . . 50 5. 1. Reproducibility of Data . . . . . . . . . . . . . . . . . . . . . . . 50 5. 2. Radiation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 5. 3. Chemical Mutagens . . . . . . . . . . . . . . . . . . . . . . . . . . Origin of Colonies . Life Cycle . Colony Maintenance . Pathology . Allergy to Grasshoppers . Grasshopper Egg, Embryo, and Cells . The Egg Shell and Membranes . Embryonic Development . Cells . Preparation of Embryos for Cell Analysis . Response of the Grasshopper Neuroblast to Mutagens . Reproducibility of Data . Chemical Mutagens . Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Paperback. Condition: new. Paperback. Frederick J. de Serres, Ph. D. Office of the Associate Director for Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms. In the past, data on chemical mutagens has been generated and published in the scientific literature on a more or less random basis. Individual chemicals enjoy a brief period of "popularity" that leads to a burst of publications in the same or sometimes related assay systems. The incompleteness of the data base, in many of these cases, makes comparative mutagenesis difficult or impossible. In our attempts to compare the genetic effects of a given chemical over a wide range of assay systems, we are often interested in making quantitative as well as qualitative compari sons. To restate the first comparison: is the chemical under ques tion a weak, moderate or potent mutagen over a wide range of assay systems--or alternatively, does the level of response vary markedly? To make the second comparison, what is needed is information on the spectrum of genetic alterations produced as well as whether this spectrum is consistent over a wide range of organisms. ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

VI: the effect of differences in genetic background an ad-3A x ad-3B crosses (S. A. Genetics 68) 1971. S. 383 - 400. m. zahlr. Abb. (St.) br. -2) Sonderabdruck.

Condition: New. In.

Publication 950. 8vo. xiii, 94 pp. Tables. Printed wrappers. Rubber stamp of contributing author Norman Horowitz. FINE.

Paperback. Condition: New.

Hardcover. Condition: Good. It's a preowned item in good condition and includes all the pages. It may have some general signs of wear and tear, such as markings, highlighting, slight damage to the cover, minimal wear to the binding, etc., but they will not affect the overall reading experience.

Condition: New. In.