Nurul Asma Abdullah (55 results)

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Taschenbuch. Condition: Neu. Neuware -Vaccine development against blood-stage antigens is aimed at inducing inhibitory antibodies towards the circulating merozoites, thus preventing them from infecting red blood cells. One such blood stage candidate is the 19 kDa C-terminus of merozoite surface protein-1 (MSP-1C). MSP-1C has been shown to induce both inhibitory as well as blocking antibodies, the latter blocking the protective effects of the former. Inhibitory antibodies will bind to MSP-1C and inhibit merozoite invasion of red blood cell but the binding of blocking antibodies can prevent binding of inhibitory antibodies thereby allowing the parasite to invade an erythrocyte. This book provides some information regarding the development of blood-stage malaria vaccine based on mutated version of MSP-1C which induces inhibitory antibodies against malarial parasite. The use of live recombinant Mycobacterium bovis bacille Calmette Guerin as a vaccine vehicle was also described in this book. The rBCG expressing the mutated version of MSP-1C was found to induce some level of protections against P. falciparum; thus paving the way for the rational use of rBCG as a blood-stage malaria vaccine candidate.Books on Demand GmbH, Überseering 33, 22297 Hamburg 180 pp. Englisch.

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Taschenbuch. Condition: Neu. Neuware -Sustainable Material for Biomedical Engineering Application discusses current interdisciplinary approaches in the development of materials and their derivatives that are sustainable for biomedical engineering application. Recent advancement of materials research has shown to have great impact on biomedical and clinical applications. With potential for sustainability, the materials discussed and illustrated in this book, may have the ability to increase and contribute to wider therapeutic options for patients. On the other hand, with the advancement in materials technology, they also have positive impacts in terms of reproducibility and more cost-effective manufacturing solutions for biomedical engineering industry. Some of the main aspects covered in this book are utilisation of human waste, food waste and green technology approach for materials in biomedical engineering applications such as tissue engineering, 3D printing and biosensing. A team of experts from various disciplines share recent advances that provide details and integrates different approaches to sustainable materials development. This book is intended for academicians, researchers, students and industrial players in the field of materials and biomedical engineering.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 520 pp. Englisch.

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Taschenbuch. Condition: Neu. Neuware -Die Impfstoffentwicklung gegen Antigene im Blutstadium zielt darauf ab, inhibitorische Antikörper gegen die zirkulierenden Merozoiten zu induzieren und so zu verhindern, dass diese rote Blutkörperchen infizieren. Ein solcher Kandidat für das Blutstadium ist der 19 kDa C-Terminus des Merozoiten-Oberflächenproteins-1 (MSP-1C). Es wurde gezeigt, dass MSP-1C sowohl inhibitorische als auch blockierende Antikörper induziert, wobei letztere die Schutzwirkung der ersteren blockieren. Inhibitorische Antikörper binden an MSP-1C und hemmen die Merozoiteninvasion roter Blutkörperchen, aber die Bindung blockierender Antikörper kann die Bindung inhibitorischer Antikörper verhindern, wodurch der Parasit in einen Erythrozyten eindringen kann. Dieses Buch enthält einige Informationen zur Entwicklung eines Malaria-Impfstoffs im Blutstadium, der auf einer mutierten Version von MSP-1C basiert und inhibitorische Antikörper gegen Malariaparasiten induziert. Die Verwendung von lebendem rekombinantem Mycobacterium bovis bacille Calmette Guerin als Impfstoffvehikel wurde ebenfalls in diesem Buch beschrieben. Es wurde gefunden, dass das rBCG, das die mutierte Version von MSP-1C exprimiert, ein gewisses Maß an Schutz gegen P. falciparum induziert; Dies ebnet den Weg für die rationelle Verwendung von rBCG als Malaria-Impfstoffkandidat im Blutstadium.Books on Demand GmbH, Überseering 33, 22297 Hamburg 184 pp. Deutsch.