An adaptive evolution strategy for protein folding

Language: English

Published by LAP LAMBERT Academic Publishing Jun 2010, 2010

3838374258 / 9783838374253

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -Proteins are a group of molecules involved in practically all biological functions that owe their versatility to the ability of binding structurally complementary ligands. Due to the limitations of experimental techniques, however, the number of resolved structures is lagging behind the number of known sequences, calling for the development of structural prediction algorithms. Since the native structure corresponds to the global minimum of the free energy function, the protein folding problem can be recast in a global optimization problem. Genetic algorithms (GA) are optimization tools that mimick the mechanism of darwinian evolution. In this work the possibility is studied to optimize the Conformational Space Annealing, a GA without mutation, with the Covariance Matrix Adaptation Evolution Strategy (CMAES), that adapts the probability distribution of mutations to the function to optimize. After improving CMAES through local minimizations and a recombination operator, the algorithm is applied to a few benchmark proteins. This book should be of interest to anyone working in computational biophysics and to those working on the improvement and application of GA. 232 pp. Englisch.…

Seller Inventory # 9783838374253

Title
An adaptive evolution strategy for protein folding
Author
Carlo Guardiani
Publisher
LAP LAMBERT Academic Publishing Jun 2010
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3838374258
ISBN 13
9783838374253
Item weight
364 grams
Dimensions
220x150x14 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

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