Urokinase receptor (uPAR) and integrin interactions in Angiogenesis

Language: English

Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Jul 2015, 2015

3838133404 / 9783838133409

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -This thesis aims at elucidating the essential role played by the urokinase receptor (uPAR) in driving VEGF induced angiogenesis. On the molecular level the formation of blood vessels from preexisting ones requires the coordinated interaction of the protease system which by their degradation of the extracellular matrix facilitates the adhesion receptors of endothelial cells to invoke migration and invasion. Using flow cytometry and immunohistochemistry based techniques we show that the protease receptor uPAR through its interaction with alpha5beta1 integrins funnels VEGF induced signals for angiogenesis. Inhibition of uPAR interaction with integrins not only impedes endothelial cell migration but also in vivo VEGF induced angiogenesis. In effect uPAR could be investigated as a potential target for angiogenesis based drug therapies. 88 pp. Englisch.

Seller Inventory # 9783838133409

Title
Urokinase receptor (uPAR) and integrin interactions in Angiogenesis
Author
Revu Alexander
Publisher
Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Jul 2015
Publication year
2015
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3838133404
ISBN 13
9783838133409
Item weight
149 grams
Dimensions
220x150x6 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

Germany