Urokinase receptor (uPAR) and integrin interactions in Angiogenesis : Urokinase receptor and Integrin interplay on endothelial cells and its implication in VEGF-induced angiogenesis
Language: English
Published by Südwestdeutscher Verlag Für Hochschulschriften, 2012
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 47.68
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Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - This thesis aims at elucidating the essential role played by the urokinase receptor (uPAR) in driving VEGF induced angiogenesis. On the molecular level the formation of blood vessels from preexisting ones requires the coordinated interaction of the protease system which by their degradation of the extracellular matrix facilitates the adhesion receptors of endothelial cells to invoke migration and invasion. Using flow cytometry and immunohistochemistry based techniques we show that the protease receptor uPAR through its interaction with alpha5beta1 integrins funnels VEGF induced signals for angiogenesis. Inhibition of uPAR interaction with integrins not only impedes endothelial cell migration but also in vivo VEGF induced angiogenesis. In effect uPAR could be investigated as a potential target for angiogenesis based drug therapies.
Seller Inventory # 9783838133409
- Title
- Urokinase receptor (uPAR) and integrin interactions in Angiogenesis : Urokinase receptor and Integrin interplay on endothelial cells and its implication in VEGF-induced angiogenesis
- Author
- Revu Alexander
- Publisher
- Südwestdeutscher Verlag Für Hochschulschriften
- Publication year
- 2012
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3838133404
- ISBN 13
- 9783838133409
- Item weight
- 149 grams
- Dimensions
- 220x150x6 mm
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