UNDERSTANDING CANCER BIOLOGY GENETICS MOLECULAR BIOLOGY AND CELLULAR SIGNALING PATHWAYS (HB 2027)

This book provides a comprehensive and current perspective on cancer research. It covers cancer biology through seven well-laid-out sections. Section I describes normal cell division, cellular homeostasis, and malignant cell transformation. Genetics, cancer epigenetics, cell cycle checkpoints, and growth-regulatory gene expression are covered in Section II. Section III discusses carcinogens, which cause cancer. Section IV describes molecular changes in cancer genes and signaling pathways, which are also employed to develop precise cancer diagnostics and treatments. Section V discusses tumor initiation, progression, metastasis, and therapeutic response, which depend on tumor cell–microenvironment interactions and their impact on disease. Section VI covers cancer diagnosis and newer, more targeted treatment. The post-genomic age and molecular methods have boosted cancer research. Section VII shows how molecular profiling, proteomics, metabolomics, and system biology may help comprehend this complex disease. This section also discusses the microbiome’s role in cancer progression and therapeutic possibilities.

Sonal Datta is a cancer biologist and protein engineer, currently a Professor in the Department of Bio-Sciences and Technology at Maharishi Markandeshwar (Deemed to be University) [MM(DU)], Mullana, Ambala, Haryana, India. She received her PhD from the Dr. B. R. Ambedkar Center for Biomedical Research at the University of Delhi, India. She was a visiting scientist at the Evanston Northwestern Healthcare Research Institute, Evanston, USA, and the University of Alabama at Birmingham, USA. Dr. Datta has published high-impact articles and book chapters. She has developed novel biosimilar and biobetter therapeutics.

Anil K. Sharma is a Professor and Dean at Amity University, Mohali, Punjab, India. He received his PhD from PGIMER, Panjab University, India. He was a visiting scientist at the University of Illinois, Chicago, USA. He has over 300 publications, an h-index of 45, 17 books, 17 patents, and numerous awards. Dr. Sharma has guided 12 PhD scholars and has been featured in Stanford University’s list of the top 2% of highly cited researchers globally.

Reena V. Saini is a cancer biologist working as a Professor in the Department of Bio-Sciences and Technology at MM(DU). She received her PhD from Dr. B. R. Ambedkar Center for Biomedical Research at the University of Delhi, India, and was a postdoctoral fellow at the NCI, National Institutes of Health, USA. She has published over 120 articles in reputed journals and book chapters.

Adesh K. Saini is the Director of the Research and Development Cell and a Professor in the Department of Bio-Sciences and Technology at MM(DU). He received his PhD from the Dr. B. R. Ambedkar Center for Biomedical Research at the University of Delhi, India, and was a postdoctoral fellow at the NICHD, National Institutes of Health, USA. He has published over 150 articles and 70 patents. He is on Stanford University’s list of the top 2% of highly cited researchers globally with an h-Index of 50.