Two Faces of Evil: Cancer and Neurodegeneration (Research and Perspectives in Alzheimer's Disease)
Language: English
Published by Springer, 2011
- Hardcover
- Used
Condition: Used - Fine
£ 26.18
Quantity: 1 available
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Edition 2011. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Edition 2011. Ammareal gives back up to 15% of this item's net price to charity organizations.
Seller Inventory # I-510-772
- Title
- Two Faces of Evil: Cancer and Neurodegeneration (Research and Perspectives in Alzheimer's Disease)
- Publisher
- Springer
- Publication year
- 2011
- Condition
- Très bon
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 3642166016
- ISBN 13
- 9783642166013
"Synopsis" may belong to another edition of this title.
From the Back Cover
The two greatest medical fears of the aging population are cancer and Alzheimer’s disease. Despite dramatic advances in understanding the molecular etiology of these disorders, therapeutic options for many patients with advanced disease have changed little and outcomes remain dismal. Paradoxically, recent findings suggest that some of the same molecules and biochemical processes underlying cancer may also participate in neurodegeneration. Therefore, it would be very useful to bring together experts from the fields of cancer research and neurodegeneration for discussions of the latest advances and ideas, with a particular emphasis on areas of overlap, to stimulate transdisciplinary interactions with the hope of accelerating progress. Cancer arises as a consequence of a breakdown in the genetic and epigenetic processes governing cell proliferation and cell death. Alterations in several classes of signaling molecules, both oncogenes and tumor suppressor genes, lead to uncontrolled cell growth. Over the past two decades, details of the intricate signaling pathways, from cell surface receptors through protein kinase cascades, transcription factors and modulators of chromatin, as well as the DNA damage response pathways linked to cell cycle control that guard the genome, have been uncovered. In some instances, key regulatory proteins have provided novel targets for development of small molecule inhibitors that are currently being tested in the clinic. The development of the nervous system relies on many of the signaling pathways and growth control processes that go awry in cancer. However, in mature neurons, the very same signaling proteins participate in transduction cascades linking short-term stimuli, elicited by synaptic stimulation, to long-term alterations in neuronal circuits through the regulation of gene expression and chromatin structure. These long-term adaptive modifications lead to changes in synapticstructure and function that contribute to learning and memory. The persistence of growth regulatory molecules in postmitotic neurons provides an opportunity for their contribution to pathophysiological processes resulting in neuronal loss. Recently, evidence has accumulated suggesting an association of cell cycle proteins and signal transduction proteins with neurodegeneration. Indeed, inhibitors of histone deacetylation have shown promise both as anti-cancer agents and in the prevention of neuronal loss
"About the title" may belong to another edition of this title.
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English below. Ammareal est une librairie professionnelle spécialisée dans le livre d’occasion. Nous expédions partout dans le monde. Nous avons plus de 250 000 ouvrages en stock dont un grand nombre de livres techniques et académiques. Nous reversons jusqu’à 15% du prix de vente de chaque livre à des organisations caritatives, des bibliothèques et des associations luttant contre l’illettrisme. Ce que nous ne vendons pas nous le donnons, ce que nous ne donnons pas nous le recyclons. Ammareal is a professional bookseller speciliazed in used books. We ship worldwide. We have more than 250 000 books in stock, including a large number of technical and university-level books. We give back up to 15% of the price of each book to charities, libraries and organizations fighting in favor of literacy. What we do not sell, we give, what we do not give we recycle.…
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Ammareal is a professional bookseller speciliazed in used books. We ship worldwide. We have more than 250 000 books in stock, including a large number of technical and university-level books. We give back up to 15% of the price of each book to charities, libraries and organizations fighting in favor of literacy. What we do not sell, we give, what we do not give we recycle.
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