Triple Repeat Diseases of the Nervous Systems

Language: English

Published by Springer, 2003

0306474174 / 9780306474170

Series: Book 114 of 544 - Advances in Experimental Medicine and Biology

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - World of Unstable Mutations The book 'Triplet Repeat Diseases of the Nervous System' overviews the lat est data on several disorders associated with unstable mutations. This field of re search is progressing extremely fast. The number of polymorphic mutations and diseases caused by these mutations is increasing almost every month. There is a strong interest to molecular bases of triplet repeat disorders. This is explained by growing necessity to develop molecular approaches for cure of these diseases. There fore, the authors of this book describe unstable mutations with the emphasis on molecular pathology. Broad discussion is presented on how polymorphic expan sions cause cell dysfunction. o The first chapter of the book focuses on the molecular pathological pro cesses that originate 'unstable' mutations. The authors review several avail able models by which normal 'stable' region of DNA become pathogenic and discuss possible mechanisms causing DNA instability. o The other chapters of the book describe inherited diseases associated with different types of unstable mutations. Based on the location of mutation in the disease gene, polymorphic expansions of the nervous system can be divided into two major groups. First group includes disorders with unstable expansions within the open reading frame of the gene such as Spinocer ebellar Ataxias caused by polyglutamine expansions. The second group in cludes diseases caused by expansions situated within the untranslated re gions of the gene.

Seller Inventory # 9780306474170

Title
Triple Repeat Diseases of the Nervous Systems
Author
Lubov T. Timchenko
Publisher
Springer
Publication year
2003
Condition
Neu
Binding
Buch
Language
English
ISBN 10
0306474174
ISBN 13
9780306474170
Item weight
467 grams
Dimensions
260x183x13 mm
Series
Book 114 of 544: Advances in Experimental Medicine and Biology

AHA-BUCH GmbH

Einbeck, Germany

5-star seller

AbeBooks seller since August 14, 2006

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