Translational Interventional Radiology, a volume in the Handbook for Designing and Conducting Clinical and Translational Research series, covers the principles of evidence-based medicine and applies these principles to the design of translational investigations in Interventional Radiology. The reader will come to fully understand important concepts including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in Interventional Radiology, and know what is needed for successful collaboration. Further, this reference is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps aspiring investigators navigate challenging considerations in study design and implementation. This book provides valuable discussions of the critical appraisal of published studies in Interventional Radiology, elucidating the evaluation of the quality with respect to measuring outcomes and making effective use of all types of evidence in patient care. In short, this practical guide will be of interest to every medical researcher and interventional radiologist who has ever had a good clinical idea but not the knowledge of how to test it.

Focuses on the principles of evidence-based medicine and applies these principles to the design of translational investigations within interventional radiology
Provides a practical, straightforward approach that helps investigators navigate challenging considerations in study design and implementation
Details discussions of the critical appraisal of published studies in interventional radiology, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care

About the Authors

Dr Adam E. M. Eltorai, MD, PhD completed his graduate studies in Biomedical Engineering and Biotechnology along with his medical degree from Brown University. His work has spanned the translational spectrum with a focus on medical technology innovation and development. Dr. Eltorai has published numerous articles and books.

Dr Liu obtained his PhD in Biostatistics from the University of Pennsylvania. Dr Liu is Associate Professor of Biostatistics and Director of the Brown ARCH Data and Statistics Core. He also is a faculty member at the biostatistics core of the Lifespan/Boston/Brown Center for AIDS Research (CFAR), Brown Data Science Initiative (DSI), Advance-Clinical Translational Research (Advance-CTR) and an affiliated faculty member for the AMPATH Biostatistics and Data Program. His research interests are in the area of health data science and include clinical decision making, incomplete data problems, causal inference, diagnostic testing, and design of clinical trials.

Sanjeeva Kalva, MD is the chief of Interventional Radiology in the Department of Radiology at Massachusetts General Hospital. He is a world-renowned expert in minimally invasive approaches to treating liver cancer. Dr. Kalva trained as an interventional radiologist in India where he served on the faculty at Kovai Medical Center and Hospital in Coimbatore. In 2004, he completed a research fellowship at Harvard Medical School followed by a fellowship in vascular and interventional radiology at Massachusetts General Hospital. He served on the faculty at Harvard Medical School and Massachusetts General Hospital until 2013 when he became the chief of Interventional Radiology at UT Southwestern Medical Center in Dallas, Texas. Dr. Kalva has published multiple research papers and book chapters in the peer-reviewed literature. His research focuses on the effectiveness of minimally invasive procedures to treat liver cancer, venous thromoboembolism, portal hypertension, varicose veins and pulmonary vascular disease including arteriovenous malformations. Dr. Kalva has won several awards for his work in interventional radiology including the Outstanding Performance Award and the Dr. Athanasoulis Award for Excellence in Teaching, both at Massachusetts
General Hospital. He is an active member of a number of professional associations including the Radiological Society of North America and the American College of Radiology and has also been named a fellow of the Society of Interventional Radiology.

Dr. Rajat Chand is a board-certified adult and pediatric interventional radiologist.

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