Transfer RNA Dynamics in Bacterial Protein Synthesis : Studies of tRNA Movement on the Ribosome During the Elongation Cycle of Bacterial Protein Synthesis
Language: English
Published by VDM Verlag Dr. Müller, 2008
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 54.97
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Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - Protein biosynthesis, also called translation,refers to mRNA-programmed synthesis of a polypeptideon the ribosome. tRNAs are required to moveefficiently between several positions on the ribosomeduring the elongation phase of translation. Althoughstructures of tRNA bound to ribosomes are available,the dynamics and mechanism of tRNA movement andstructural change are incompletely understood. Theclassic L-shape of tRNA undergoes considerabledistortion during the elongation cycle, leading tothe suggestion that the tRNA tertiary core region,which stabilizes the L-shape, actively interacts withthe ribosome. Here, using fluorescence labeling oftRNA and mutagenesis of highly conserved nucleotideswithin the tertiary core, combined with binding andsingle turnover rapid kinetics assays, we monitortRNA movement on the ribosome, examine the importanceof the tertiary core region for each step of theelongation cycle, identify interactions andintermediates that are important for the accuracy andefficiency of protein biosynthesis, and determineantibiotic effects on elongation.…
Seller Inventory # 9783639085037
Bibliographic details
- Title
- Transfer RNA Dynamics in Bacterial Protein Synthesis : Studies of tRNA Movement on the Ribosome During the Elongation Cycle of Bacterial Protein Synthesis
- Author
- Dongli Pan
- Publisher
- VDM Verlag Dr. Müller
- Publication year
- 2008
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3639085035
- ISBN 13
- 9783639085037
- Item weight
- 255 grams
- Dimensions
- 220x176x33 mm
Shipping rates from Germany to U.S.A.
| Item | 7 to 10 business days | 5 to 7 business days |
|---|---|---|
| First item | £ 30.10 | £ 38.71 |
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