Transcription Induction Integrated by Nuclear Receptor Coregulators : Chromatin, SF-1, and CtBP Structural and Post- Translational Modifications Induced by ACTH/cAMP Accelerate CYP17 Transcription Rate
Language: English
Published by VDM Verlag Dr. Müller, 2009
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
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nach der Bestellung gedruckt Neuware - Printed after ordering - Studies carried out during the past decade have shown that transcription of inducible eukaryotic genes involves sequential chromatin modifications by promoter-specific transcription factors and a class of proteins called transcription coregulators. First, this work identifed important chromatin modifications and modifying complexes at the CYP17 transcription start site and nearby steroidogenic factor-1 (SF-1) binding site. Post translational modifications (PTMs) to SF-1 also occur as this transcription factor interacts with the promoter. In addition, ACTH/cAMP signaling in adrenal cortex alters SF-1-containing chromatin-modifying complexes during the early phase of transcriptional induction of CYP17. Chromatin IP (ChIP) and mammalian two hybrid experiments identified complexes which are cAMP-inducible, but sensitive to the SF-1 antagonist sphingosine. SF-1 PTMs at the ligand binding pocket opening were found to be required for CYP17 transcription. Last, certain corepressors are protein kinase A (PKA) targets and are functionally sensitive to PKA-dependent NADH accumulation. Thus, signaling, metabolism, and transcription are integrated.…
Seller Inventory # 9783836475327
- Title
- Transcription Induction Integrated by Nuclear Receptor Coregulators : Chromatin, SF-1, and CtBP Structural and Post- Translational Modifications Induced by ACTH/cAMP Accelerate CYP17 Transcription Rate
- Author
- Eric Dammer
- Publisher
- VDM Verlag Dr. Müller
- Publication year
- 2009
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3836475324
- ISBN 13
- 9783836475327
- Item weight
- 267 grams
- Dimensions
- 22.00x15.00x1.00 cm
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