Thyroid Hormone Disruption and Neurodevelopment
Language: English
Published by Springer, 2016
- Hardcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 179.51
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Add to basketItem description from seller
Druck auf Anfrage Neuware - Printed after ordering - Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first bookto comprehensively describethe effect of thyroid hormone disruptionin the central nervous system.The first section deals with the disruption of thyroid hormone action at themolecular level. Firstthe authorsprovide a summary ofthe possible molecular mechanisms of thyroid hormone action in the brain, thenthey discussseveral factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a'repressor' of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanismsthat createeach abnormal phenotype are not fully understood.…
Seller Inventory # 9781493937356
- Title
- Thyroid Hormone Disruption and Neurodevelopment
- Author
- Noriyuki Koibuchi
- Publisher
- Springer
- Publication year
- 2016
- Condition
- Neu
- Binding
- Buch
- Language
- English
- ISBN 10
- 1493937359
- ISBN 13
- 9781493937356
- Item weight
- 448 grams
- Dimensions
- 241x160x18 mm
- Series
- Book 13 of 20: Contemporary Clinical Neuroscience
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