Taurine 4 | Taurine and Excitable Tissues

Laura Della Corte (u. a.)

ISBN 10: 1475773420 / ISBN 13: 9781475773422

Published by Springer, 2013

Taurine 4 | Taurine and Excitable Tissues | Laura Della Corte (u. a.) | Taschenbuch | xxiv | Englisch | 2013 | Springer | EAN 9781475773422 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. Seller Inventory # 105652441

Synopsis:

Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the “setpoint” andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

Bibliographic Details

Title: Taurine 4 | Taurine and Excitable Tissues
Publisher: Springer
Publication Date: 2013
Binding: Taschenbuch
Condition: Neu