Targeting Functional Centers of the Ribosome

Language: English

Published by Springer Berlin Heidelberg Apr 2013, 2013

364226705X / 9783642267055

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This item is printed on demand - it takes 3-4 days longer - Neuware -This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself. 88 pp. Englisch.

Seller Inventory # 9783642267055

Title
Targeting Functional Centers of the Ribosome
Author
Chen Davidovich
Publisher
Springer Berlin Heidelberg Apr 2013
Publication year
2013
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
364226705X
ISBN 13
9783642267055
Item weight
149 grams
Dimensions
235x155x6 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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