Targeting Functional Centers of the Ribosome

Language: English

Published by Springer Berlin Heidelberg Feb 2011, 2011

3642169309 / 9783642169304

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This item is printed on demand - it takes 3-4 days longer - Neuware -This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself. 88 pp. Englisch.

Seller Inventory # 9783642169304

Title
Targeting Functional Centers of the Ribosome
Author
Chen Davidovich
Publisher
Springer Berlin Heidelberg Feb 2011
Publication year
2011
Condition
Neu
Binding
Buch
Language
English
ISBN 10
3642169309
ISBN 13
9783642169304
Item weight
323 grams
Dimensions
241x160x9 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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