Targeted Biomarker Quantitation by LC-MS (Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods)
Language: English
Published by Wiley, 2017
- Hardcover
- New
Seller: Fulano Books, Cambridge, MA, U.S.A.Fulano Books
AbeBooks seller since August 21, 2024
Condition: New
£ 126.35
Quantity: 1 available
Add to basketSeller Inventory # HG-RDM2-DMMX
- Title
- Targeted Biomarker Quantitation by LC-MS (Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods)
- Publisher
- Wiley
- Publication year
- 2017
- Condition
- New
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 1119103061
- ISBN 13
- 9781119103066
- Series
- Book 8 of 9: Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms
The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development.
Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation―a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell.
- Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis
- Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges
- Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection
- Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation
- Highlights the current state of the biomarker regulatory environment and protocol standards
Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.
"Synopsis" may belong to another edition of this title.
About the Author
Naidong Weng, PhD, is Scientific Director, Janssen Fellow, and Head of Bioanalytical Chemistry and Pharmacokinetics within Department of Pharmacokinetics, Dynamics and Metabolism at US East Coast, Janssen Research & Development, Johnson and Johnson. He has over 25 years of experiences on quantitative bioanalysis. His research interest includes using HILIC-MS/MS for quantitation of highly polar analytes as well as chiral analysis. He has published more than 110 journal papers and book chapters.
Wenying Jian, PhD, a Senior Principal Scientist of Bioanalytical Chemistry and Pharmacokinetics within Department of Pharmacokinetics, Dynamics and Metabolism at US East Coast, Janssen Research & Development, Johnson and Johnson. Her research experience and interest center on application of advanced LC-MS methodologies in detection, identification, and quantitation of endogenous molecules, drugs and their metabolites, including small and large molecules, and in complicated biological matrices. She has published more than 40 journal papers and book chapters.
"About the title" may belong to another edition of this title.
Fulano Books
Cambridge, MA, U.S.A.
AbeBooks seller since August 21, 2024
Shipping rates within U.S.A.
| Item | 5 to 10 business days | 2 to 5 business days |
|---|---|---|
| First item | £ 4.56 | £ 9.14 |
Payment methods
Store description
Family-run business of true bibliophiles, with a hand-curated inventory of the finest titles. We believe in the beauty of books--not just in their words, but in the elegance, timelessness, even the smell of a well-kept piece. As such, we strive to keep nothing on our shelves you wouldn't be proud to put on yours.
Specialty
VariedSeller's business information
Fulano Books
MA, U.S.A.
Terms of sale
Quality hard-to-find books, out-of-print volumes, and even the newer stuff.
Right of withdrawal
If you are a consumer you can withdraw from the contract in accordance with the following. Consumer means any natural person who is acting for purposes which are outside his trade, business, craft or profession.
Information regarding the right of withdrawal
Statutory right to withdraw
You have the right to withdraw from this contract within 14 days without giving any reason.
The withdrawal period will expire after 14 days from the day on which you acquire, or a third party other than the carrier and indicated by you acquires, physical possession of the last good or the last lot or piece.
To exercise the right of withdrawal, electronically fill in and submit a clear statement on our website, under "My Purchases" in "My Account". We will communicate to you an acknowledgement of receipt of such a withdrawal on a durable medium (e.g. by e-mail) without delay.
To meet the withdrawal deadline, it is sufficient for you to send your communication concerning your exercise of the right of withdrawal before the withdrawal period has expired.
Effects of withdrawal
If you withdraw from this contract, we will reimburse to you all payments received from you, including the costs of delivery (except for the supplementary costs arising if you chose a type of delivery other than the least expensive type of standard delivery offered by us).
We may make a deduction from the reimbursement for loss in value of any goods supplied, if the loss is the result of unnecessary handling by you.
We will make the reimbursement without undue delay, and not later than 14 days after the day on which we are informed about your decision to withdraw from this contract.
We will make the reimbursement using the same means of payment as you used for the initial transaction, unless you have expressly agreed otherwise; in any event, you will not incur any fees as a result of such reimbursement.
We may withhold reimbursement until we have received the goods back, or you have supplied evidence of having sent back the goods, whichever is the earliest.
You shall send back the goods or hand them over to Fulano Books, Cambridge, Massachusetts, U.S.A., without undue delay and in any event not later than 14 days from the day on which you communicate your withdrawal from this contract to us. The deadline is met if you send back the goods before the period of 14 days has expired. You will have to bear the direct cost of returning the goods. You are only liable for any diminished value of the goods resulting from the handling other than what is necessary to establish the nature, characteristics and functioning of the goods.
Exceptions to the right of withdrawal
The right of withdrawal does not apply to:
- The delivery of newspapers, journals or magazines with the exception of subscription contracts; and
- The supply of digital content which is not supplied on a tangible medium (e.g. on a CD or DVD) if you accepted when you placed your order that we could start to deliver it, and that you could not withdraw once delivery had started.
Shipping terms
Standard shipping is USPS media mail unless otherwise selected. All items are sent in heavy duty bubble-padded mailers. Heavier and larger items are mailed in boxes with appropriate wrap to ensure safe delivery.