Tachykinins

Language: English

Published by Springer, 2012

3642623425 / 9783642623424

Series: Book 51 of 124 - Handbook of Experimental Pharmacology

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - More than 70 years have elapsed since U. S. von Euler and I. H. Gaddum dis covered an unidentified depressor substance in the brain and gut. The effects of the powdery extracts were marked as 'P' on the kymograph tracings, and the nondescript name of 'substance P' still carries the breath of this adventurous period. In the 1960s, substance P returned in another disguise, staging as a hypothalamic peptide that causes copious salivary secretion (see chapter by F. Lembeck and I. Donnerer). This time, though, the mysterious substance was tracked down by S. E. Leeman and her collaborators as an undecapeptide, after it had eluded its identification for some 40 years. Substance P turned out to be the mammalian counterpart of a family of peptides which had been extracted from amphibian and nonvertebrate species and which had been given the name 'tachykinins' by V. Erspamer. Soon novel members of this peptide family were discovered, and in mammals substance P was joined by neurokinin A and neu rokinin B. The presence of tachykinins in frog skin as well as in venoms and toxins of microbes and arachnids raises the possibility that these peptides re present an old system of biological weapons that have been transformed to a particular messenger system in mammals.

Seller Inventory # 9783642623424

Title
Tachykinins
Author
Peter Holzer
Publisher
Springer
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3642623425
ISBN 13
9783642623424
Item weight
873 grams
Dimensions
235x155x32 mm
Series
Book 51 of 124: Handbook of Experimental Pharmacology

AHA-BUCH GmbH

Einbeck, Germany

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