Systems Biology Approaches: Prevention, Diagnosis, and Understanding Mechanisms of Complex Diseases

This book examines the development and applications of system biology approaches for the prevention, diagnosis, and understanding of disease mechanisms. It explores the applications of system biology in infectious diseases, including host-pathogen interaction, and the identification of targets for new therapeutics and intervention strategies. It covers the use of system biology for understanding and treating metabolic disorders towards personalized and precision medicine. The book further discusses the systems biology approaches for understanding the mechanisms of tumor progression and designing more effective cancer therapies. The chapter also reviews the current strategies in autoimmune disease treatment and highlights the opportunity that systems biology represents for the development of better and safer treatments. Importantly, the book discusses the current state of the systems-level understanding of diseases and both the therapeutic and adverse mechanisms of drug actions usingsystem biology approaches. Cutting across the disciplines, this book is a valuable source for researchers in genetics, molecular biology, cell biology, microbiology, and biomedical sciences.

Sanket Joshi is currently serving as a Professor and Deputy Director, at Amity Institute of Microbial Technology, Amity University Rajasthan, Jaipur, India. He served as Deputy Director, Oil & Gas Research Center (2018-2023), and an Application Specialist, at Central Analytical and Applied Research Unit, Sultan Qaboos University, Oman (2013-2023). Prof. Joshi has 18 years of academic teaching and research experience, and 4 years of industrial R&D experience, in India and Oman. While working in Indian pharma companies, he undertook several turnkey projects (both upstream and downstream) on antibiotics (β-lactams, macrolides, glycopeptides), antidiabetic drug (for type II diabetes), and Co-enzyme Q10. His current research interests encompass: Energy; Microbial products; and Environmental bioremediation. He serves as an Academic/Associate Editor for some of the highly reputed journals, and  awarded as “NRI Senior Scientist Award”, from Microbiologists Society, India, during academic year, 2019-2020. Prof. Joshi was listed among the 2% of the "Stanford University – Elsevier” list of the highly cited scientists in the world for - 2022 and 2023, for excellence in scientific research in ‘Energy’ and ‘Biotechnology’ disciplines.

Dr. Rina Rani Ray joined the Department of Biotechnology as associate professor in 2017. She has done her doctoral research in the Department of Microbiology, Bose Institute, Kolkata, India and was awarded Ph.D. degree from University of Calcutta in 1996. Since then, she is working on different branches of microbiology including enzyme biotechnology, metal bioremediation and fungal biotechnology. She has published more than 75 research papers in various national and international journals. She is in the editorial board of many reputed journals. She is the member of various scientific associations and was nominated fellows of Zoological Society, India and Academy for Environment and Life Sciences, India.

Dr. Moupriya Nag is presently working as assistant professor in the department of biotechnology, University of Engineering & Management, Kolkata, India. Her Postdoctoral work was focused on exploring the aggregation kinetics and mechanism of action of peptides associated with neurodegenerative diseases in presence of various membrane surfaces with solution NMR. Her research interests include single molecule Biophysics of protein unfolding/refolding and protein aggregation kinetics and its mechanism of action especially the amyloid proteins in neurodegenerative disorders. Recently, her research focuses on functional amyloids in bacteria and their relation in forming biofilms. Her work deals with developing novel antimicrobial and anti-biofilm compounds from natural sources including plants, microbes and green synthesized nanoparticles. She has about 5 years of teaching experience in biophysics, bioinformatics, bioprocess and biotechnology, enzyme technology, computing, molecular modeling, and drug design. She has also published many research articles in the peer-reviewed international journal and authored or co-authored numerous book chapters. She is also a member of many scientific societies like Indian Biophysical Society and Indian Science Congress Association.

Dr. Dibyajit Lahiri is working as assistant professor in the department of biotechnology, University of Engineering & Management, Kolkata, India. He has experience of working with various chromatographic techniques and isolation of bioactive compounds from different plant samples. His current research interest is precisely on biofilm isolated from human prosthesis and its inhibition by various novel ‘phyto and nano’ compounds. He is keen to explore the molecular mechanism behind the removal of biofilm by natural compounds. His research arena also encompasses computational drug development by using bioinformatics. Dr. Lahiri was awarded best teacher award and best paper awardsfrom UEM, Kolkata. He is a life Member of Indian Science Congress Association and Institution of Engineers (India).