The Synapse: Structure and Function (Neuroscience-Net Reference)

Virginia Pickel,Menahem Segal

ISBN 10: 0124186750 / ISBN 13: 9780124186750

Published by Academic Press Inc 2014-01-29, 2014

About this Item

Seller Inventory # 6666-ELS-9780124186750

Bibliographic Details

Title: The Synapse: Structure and Function (...

Publisher: Academic Press Inc 2014-01-29

Publication Date: 2014

Binding: Hardcover

Condition: New

About this title

Synopsis:

The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases.

• Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses.
• Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis.
• Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations.
• Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function.

Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings.

• A comprehensive reference focused on the structure and function of the synapse
• Covers the links between the synapse and neural plasticity and the cellular basis of neurologic disease
• Detailed coverage of dendritic spines and associated perisynaptic glia―the tripartite synapse
• Includes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment

Review:

A foundational collection of focused chapters detailing the science of the synapse