Structure-Function Analysis of G Protein-Coupled Receptors
Language: English
Published by Wiley Jun 1999, 1999
- Hardcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 389.34
Quantity: 1 available
Add to basketItem description from seller
Neuware - G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, often playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity. This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters. Divided into specific, accessible sections, Structure-Function Analysis of G Protein-Coupled Receptors includes: \* An overview of mutagenesis techniques \* Examples of molecular modeling techniques \* Using peptides as tools for the study of GPCR interactions \* Site-Directed Spin Labeling (SDSL) studies of the GPCR rhodopsin \* A complete description of the electron-crystalographic analysis of two-dimensional rhodopsin crystals \* The use of nuclear magnetic resonance techniques to study GPCR structure; Uber 40 Prozent der gegenwartig von Pharmakonzernen untersuchten pharmakologischen Targets stehen im Zusammenhang mit G-Protein-gekoppelten Rezeptoren (GPCRs). Bei der Untersuchung von Struktur, Eigenschaften und Funktion der GPCRs hilft dieser Band, der die aktuellsten molekulargenetischen, biochemischen und biophysikalischen Methoden zusammenfa t. Die erfahrenen Autoren bewerten jedes vorgestellte Verfahren im Hinblick auf verschiedene Anwendungen. (08/99).…
Seller Inventory # 9780471252283
- Title
- Structure-Function Analysis of G Protein-Coupled Receptors
- Author
- Jürgen Wess
- Publisher
- Wiley Jun 1999
- Publication year
- 1999
- Condition
- Neu
- Binding
- Buch
- Language
- English
- ISBN 10
- 047125228X
- ISBN 13
- 9780471252283
- Item weight
- 984 grams
- Dimensions
- 261x186x25 mm
This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters.
Divided into specific, accessible sections, Structure-Function Analysis of G Protein-Coupled Receptors includes:
* An overview of mutagenesis techniques
* Examples of molecular modeling techniques
* Using peptides as tools for the study of GPCR interactions
* Site-Directed Spin Labeling (SDSL) studies of the GPCR rhodopsin
* A complete description of the electron-crystalographic analysis of two-dimensional rhodopsin crystals
* The use of nuclear magnetic resonance techniques to study GPCR structure
"Synopsis" may belong to another edition of this title.
About the Author
Jürgen Wess is the author of Structure-Function Analysis of G Protein-Coupled Receptors, published by Wiley.
"About the title" may belong to another edition of this title.
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