The Structural Basis of Arrestin Functions. This item is unavailable.
Language: English
Published by Springer International Publishing, 2018
- Softcover
- New
Seller: moluna, Greven, Germanymoluna
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Softcover
Condition: New
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Item description from seller
Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Gives a unique insight of the connection between protein structure and function of arrestin and its broad implicationsDiscussed are structure-based redesign of signalling proteins paves the way for novel approaches to gene therapy.
Seller Inventory # 458626494
- Title
- The Structural Basis of Arrestin Functions
- Author
- Gurevich, Vsevolod V.
- Publisher
- Springer International Publishing
- Publication year
- 2018
- Condition
- New
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 3319861913
- ISBN 13
- 9783319861913
- Seller catalogs
- Mathematik/Naturwissenschaften/Technik/Medizin
Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death.
Here arrestin functions are described primarily from the structural prospective.
Here arrestin functions are described primarily from the structural prospective.
"Synopsis" may belong to another edition of this title.
About the Author
Dr. Gurevich got his PhD in Bioorganic Chemistry at the Shemyakin Institute in Moscow. He studied structure and function of arrestin proteins since he joined the lab of Dr. Benovic as a post-doc in 1991. Dr. Gurevich’s studies revealed why arrestins prefer active phosphorylated GPCRs and how they sense receptor-attached phosphates. His lab constructed phosphorylation-independent arrestin mutants and tested their ability to compensate for the defects of GPCR phosphorylation. His lab elucidated the structural basis of arrestin preference for particular GPCRs and constructed the first non-visual arrestins with high receptor specificity. In collaboration with different crystallographers Dr. Gurevich’s lab solved the structures of all four vertebrate arrestins in basal conformation and the structure of the arrestin-rhodopsin complex.
"About the title" may belong to another edition of this title.