Stem Cells in Modeling Human Genetic Diseases
Language: English
Published by Springer, 2015
Series: Book 39 of 72 - Stem Cell Biology and Regenerative Medicine
- Hardcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
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Druck auf Anfrage Neuware - Printed after ordering - While most stem cell books focus on basic aspects and/or cell therapy, this book emphasizes the relevance of stem cells obtained from patients, the so-called 'patients in a petri dish' as tools to investigate human genetic diseases for which there are no available effective treatment. Chapters embrace several examples of the use of iPS cell technology, a recent Nobel Prize-winning scientific breakthrough, to obtain patient-specific pluripotent cells from which many types of specialized cells involved in a particular disease can be generated, including psychiatric and neurodegenerative disorders, muscular dystrophies, laminopathies, among others. The text is a current and timely resource for postgraduate students, scientists and clinicians, interested in applications of this rapidly developing field of research in disease modeling, drug development, and emerging issues that it brings to regenerative medicine.
Seller Inventory # 9783319183138
- Title
- Stem Cells in Modeling Human Genetic Diseases
- Author
- Mayana Zatz
- Publisher
- Springer
- Publication year
- 2015
- Condition
- Neu
- Binding
- Buch
- Language
- English
- ISBN 10
- 3319183133
- ISBN 13
- 9783319183138
- Item weight
- 442 grams
- Dimensions
- 241x160x14 mm
- Series
- Book 39 of 72: Stem Cell Biology and Regenerative Medicine
"Synopsis" may belong to another edition of this title.
About the Author
Dr. Mayana Zatz is a professor of Human and Medical Genetics and is currently the director of the Human Genome Research Center and Institute of stem-cells in genetic disorders, at the University of São Paulo. She completed a Ph.D. in Human and Medical Genetics there and was a post-doc in medical genetics at the University of California. Her research in human and medical genetics focuses mainly on the following aspects of neuromuscular disorders: novel genes identification, genotype-phenotype correlations, mechanisms of clinical variability and stem-cells as a tool to understand gene expression and their therapeutic applications. She published about 300 peer-reviewed papers that were cited 8700 times ( h=43). She has been actively involved in ethical aspects related to genome research, genetic testing and political decisions regarding the approval of the Brazilian embryonic stem-cell bill by the Congress in 2005 and by the Supreme Court in 2008.
Dr. O. Keith Okamoto is a professor in the Department of Genetics and Evolutionary Biology at the University of São Paulo (USP). Prior to joining the University, he was a professor of Neurosciences at the Medical School of the Federal University of São Paulo. He earned his Ph.D. in Biochemistry and Molecular Biology at the USP and he conducted research as a postdoctoral fellow in the Department of Molecular and Cellular Biology at Harvard University, where he was also affiliated to the Harvard’s Bauer Center for Genomics Research. Dr. Okamoto is a member of the Brazilian Cell Therapy Network, and head of the Translational Genomics Laboratory at USP. His current research focuses on the interplay between stem cell biology and cancer, with emphasis on the genetic and molecular mechanisms inducing a stem cell-like phenotype in cancer cells, their role in tumor heterogeneity and aggressiveness, and the contribution of normal stem cells to tumor development and metastasis. Preclinical therapy studies for cancer and some neurological disorders comprise another major scientific interest of his group.
"About the title" may belong to another edition of this title.
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