Spinal Interneurons : Plasticity After Spinal Cord Injury
Language: English
Published by Elsevier Science, 2022
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Seller Inventory # 9780128192603
- Title
- Spinal Interneurons : Plasticity After Spinal Cord Injury
- Author
- Michael Aron Lane
- Publisher
- Elsevier Science
- Publication year
- 2022
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 0128192607
- ISBN 13
- 9780128192603
- Item weight
- 748 grams
- Dimensions
- 230x152x24 mm
The spinal cord is comprised of four types of neurons: motor neurons, pre-ganglionic neurons, ascending projection neurons, and spinal interneurons. Interneurons are neurons that process information within local circuits, and have an incredible ability for neuroplasticity, whether due to persistent activity, neural injury, or in response to disease. Although, by definition, their axons are restricted to the same structure as the soma (in this case the spinal cord), spinal interneurons are capable of sprouting and rewiring entire neural circuits, and contribute to some restoration of disrupted neural communication after injury to the spinal cord (i.e., “bypassing the lesion site).
Spinal Interneurons provides a focused overview of how scientists classify interneurons in general, the techniques used to identify subsets of interneurons, their roles in specific neural circuits, and the scientific evidence for their neuroplasticity. Understanding the capacity for neuroplasticity and identity of specific spinal interneurons that are optimal for recovery, may help determine cellular candidates for developing therapies.
Spinal Interneurons provides neuroscientists, clinicians, and trainees a reference book exclusively concentrating on spinal interneurons, the techniques and experiments employed to identify and study these cells as part of normal and compromised neural circuits, and highlights the therapeutic potential of these cells by presenting the relevant pre-clinical and clinical work to date. People in industry will also benefit from this book, which compiles the latest in therapeutic strategies for targeting spinal interneurons, what considerations there are for the development and use of treatments, and how such treatments can not only be translated to the clinic, but how existing treatments should be appropriately reverse-translated to the bench.
- Comprehensive overview of techniques used to identify, characterize, and classify spinal interneurons and their role in neural circuits
- Description of the role that spinal interneurons play in mediating plasticity after compromise to spinal neural networks
- In-depth discussion of therapeutic potential of spinal interneurons for spinal cord injury and/or disease
"Synopsis" may belong to another edition of this title.
About the Author
Dr. Michael Aron Lane is an Associate Professor in the Department of Neurobiology and Anatomy at the Drexel University College of Medicine. He is a Primary Investigator in the Marion Murray Spinal Cord Research Center, where his research team is investigating the neuroplastic potential after spinal cord injury, and developing strategies to promote repair and recovery (e.g., activity-based therapies, neuromodulation and cellular transplantation). He is committed to maintaining a translational focus to his pre-clinical research and retains close ties with scientists, engineers, clinical professionals and people living with spinal cord injury. He is also deeply invested in the training of future scientists having served in multiple external workshops and courses on spinal cord injury, serving as co-director of a Neuroscience Summer Camp for High School students, and Co-Director of a graduate training program for spinal cord injury research funded by the National Institutes of Health.
"About the title" may belong to another edition of this title.
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