Spectroscopic Studies of Structure and Function of the Light-Gated Cation Channel Channelrhodopsin-2
Language: English
Published by Cuvillier, 2014
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 37.40
Quantity: 1 available
Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - Revealing structural and mechanistic details of Channelrhodopsin-2 (ChR2) is in the focus of current scientific research due to its unique ability to stimulate cell activity by light (optogenetics). Hence, ChR2 is a promising tool to revolutionize medical treatment. The aim of this work was the investigation of the light-activated mechanism of the retinylidene cation channel ChR2 on an atomistic level by means of vibrational spectroscopy.In addition to successful expression and purification of ChR2, resonance Raman and FTIR spectroscopy elucidated the structure of the chromophore binding pocket as well as the gating mechanism triggered by a single hydrogen bond between two residues ('DC gate'). Therefore, FTIR difference spectroscopic results were correlated with time-resolved UV/Vis spectroscopy. Flash photolysis allowed characterization of the time scale of proton release with subsequent uptake using an indicator dye.Application and modification of advanced biophysical techniques such as surface-enhanced FTIR, single-molecule force spectroscopy and doubly vibrationally-enhanced four wave mixing set the basis to obtain even deeper insights into the structure and function of membrane proteins like ChR2.…
Seller Inventory # 9783954046355
- Title
- Spectroscopic Studies of Structure and Function of the Light-Gated Cation Channel Channelrhodopsin-2
- Author
- Melanie Hey
- Publisher
- Cuvillier
- Publication year
- 2014
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3954046350
- ISBN 13
- 9783954046355
- Item weight
- 309 grams
- Dimensions
- 210x148x13 mm
"Synopsis" may belong to another edition of this title.
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| Item | 30 to 40 business days | 7 to 14 business days |
|---|---|---|
| First item | £ 52.78 | £ 61.35 |
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