Single-Molecule Enzymology: Fluorescence-Based and High-Throughput Methods
Language: English
Published by Elsevier Science Publishing Co Inc, US, 2016
Series: Book 215 of 272 - ISSN
- Hardcover
- New
Seller: Rarewaves.com UK, London, United KingdomRarewaves.com UK
AbeBooks seller since June 11, 2025
Condition: New
£ 210.61
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Add to basketItem description from seller
Single-Molecule Enzymology, Part A, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in single-molecule enzymology, and includes sections on such topics as force-based and hybrid approaches, fluorescence, high-throughput sm enzymology, nanopores, and tethered particle motion.
Seller Inventory # LU-9780128092675
- Title
- Single-Molecule Enzymology: Fluorescence-Based and High-Throughput Methods
- Author
- Maria Spies
- Publisher
- Elsevier Science Publishing Co Inc, US
- Publication year
- 2016
- Condition
- New
- Binding
- Hardback
- Language
- English
- ISBN 10
- 012809267X
- ISBN 13
- 9780128092675
- Item weight
- 1,130 grams
- Series
- Book 215 of 272: ISSN
- Continues the legacy of this premier serial with quality chapters authored by leaders in the field
- Covers research methods in single-molecule enzymology
- Contains sections on such topics as force-based and hybrid approaches, fluorescence, high-throughput sm enzymology, nanopores, and tethered particle motion
"Synopsis" may belong to another edition of this title.
About the Author
Spies’ research career has been focused on deciphering the intricate choreography of the molecular machines orchestrating the central steps in the homology directed DNA repair. Her doctoral research supported by the Japanese Government (MONBUSHO) Graduate Scholarship provided the first detailed biochemical characterization of archaeal recombinase RadA. In her postdoctoral work with Dr. Steve Kowalczykowski (UC Davis) supported by the American Cancer Society, Spies reconstituted at the single-molecule level the initial steps of bacterial recombination and helped to explain how this process is regulated.
Spies’ laboratory at the University of Iowa emphasizes the molecular machinery of homologous recombination, how it is integrated into DNA replication, repair and recombination (the 3Rs of genome stability), and how it is misappropriated in the molecular pathways that process stalled DNA replication events and DNA breaks through highly mutagenic, genome destabilizing mechanisms. Her goal is to understand, reconstitute and manipulate an elaborate network of DNA recombination, replication and repair, and to harness this understanding for anticancer drug discovery. The Spies lab utilizes a broad spectrum of techniques from biochemical reconstitutions of the key biochemical reactions in DNA recombination, repair and replication, to structural and single-molecule analyses of the proteins and enzymes coordinating these reactions, to combined HTS/CADD campaigns targeting human DNA repair proteins.
Work in Spies Lab has been funded by the American Cancer Society (ACS), Howard Hughes Medical Institute (HHMI), and is currently supported by the National Institutes of Health (NIH). She received several prestigious awards including HHMI Early Career Scientist Award and Margaret Oakley Dayhoff Award in Biophysics. She serves on the editorial board of the Journal of Biological Chemistry, and as an academic editor of the journal Plos-ONE. She is a permanent member and a chair of the American Cancer Society “DNA mechanisms in cancer review panel.
Associate Professor of Physics and Biophysics, Department of Physics, University of Illinois at Urbana-Champaign, USA
"About the title" may belong to another edition of this title.
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London, United Kingdom
AbeBooks seller since June 11, 2025
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