Short-Term Test Systems for Detecting Carcinogens

Language: English

Published by Springer Berlin Heidelberg, 2011

3642672043 / 9783642672040

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Druck auf Anfrage Neuware - Printed after ordering - The varying cancer incidence from country to country and region to region suggests that en vironmental factors play a considerable role in the aetiology of cancer. Whether these factors in the environment moderate the effect of car cinogenic chemicals or whether they might them selves be carcinogenic is not known at the present time. What is known is that there are various chemicals, both naturally occurring and man-made, which can induce cancer in man. In the Western world estimates vary as to how much cancer is occupational in origin; the figures range from 1% to 40%. It is our feeling that probably about 10% of cancer has a direct oc cupational origin. Nevertheless this number is considerable and it behoves us therefore to identify those chemicals which are carcinogenic and to reduce human exposure. Recent work on the mode of action of carcinogenic chemicals suggests that the majority exert their effect through an activation step to give elec trophilic metabolites. Such metabolites have as a common feature the ability to react with cel lular nucleophiles to give covalently bound products. Such reaction will occur after carcino gen treatment of animals with nucleic acids par ticularly in target organs. It is reaction with nucleic acids that provides the basis of a num ber of short-term tests for carcinogens, since the basic composition of DNA is similar in micro-organisms and in human cells.

Seller Inventory # 9783642672040

Title
Short-Term Test Systems for Detecting Carcinogens
Author
K. H. Norpoth
Publisher
Springer Berlin Heidelberg
Publication year
2011
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3642672043
ISBN 13
9783642672040
Item weight
748 grams
Dimensions
244x170x24 mm

AHA-BUCH GmbH

Einbeck, Germany

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