In Search of Selective 11¿-HSD 1 Inhibitors without Nephrotoxicity
Language: English
Published by LAP LAMBERT Academic Publishing Okt 2015, 2015
- Softcover
- New
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
AbeBooks seller since January 11, 2012
Condition: New
£ 34.72
Quantity: 2 available
Add to basketItem description from seller
This item is printed on demand - it takes 3-4 days longer - Neuware -Over expression of 11beta-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11beta-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11beta-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11beta-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski's rule and ADME prediction implemented to find out the potent and selective 11 beta-HSD 1 analog of corosolic acid without nephrotoxicity. 56 pp. Englisch.
Seller Inventory # 9783659790010
- Title
- In Search of Selective 11¿-HSD 1 Inhibitors without Nephrotoxicity
- Author
- Rakesh Jagtap
- Publisher
- LAP LAMBERT Academic Publishing Okt 2015
- Publication year
- 2015
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 365979001X
- ISBN 13
- 9783659790010
- Item weight
- 102 grams
- Dimensions
- 220x150x4 mm
"Synopsis" may belong to another edition of this title.
About the Author
"About the title" may belong to another edition of this title.
BuchWeltWeit Ludwig Meier e.K.
Bergisch Gladbach, Germany
AbeBooks seller since January 11, 2012
Shipping rates from Germany to U.S.A.
| Item | 5 to 15 business days | 5 to 15 business days |
|---|---|---|
| First item | £ 19.43 | £ 19.43 |
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BuchWeltWeit Ludwig Meier e.K.
Germany
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