SUSTAINED RELEASE TABLETS : Use of Natural Gums
Language: English
Published by LAP LAMBERT Academic Publishing, 2011
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
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Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - The present study was undertaken to develop oral sustained release tablets of metoprolol tartrate using natural hydrophilic matrix formers (xanthan gum and tragacanth). Sustained release matrix tablets of metoprolol tartrate were prepared by using different ratios of drug, xanthan gum and tragacanth. Microcrystalline cellulose (MCC) was used as diluent. The polymer was incorporated into a matrix system using direct compression technique. Different formulations were evaluated with respect to dissolution profile in 900 mL phosphate buffer (pH 6.8), 0.1 M HCl solution and distilled water for 12 h at 37°C. Increasing the amount of polymer (xanthan gum) in the formulation led to slow release of drug. The kinetic treatment showed the best fitted different mathematical models (Zero order, First order, Higuchiís and Hixson-Crowell). Most of the solid matrix formulations followed Higuchi or zero order kinetics. The formulations F1, F2, F3 and F7, F8, F9 showed maximum linearity. The results showed that the formulation F9 containing 30% xanthan gum and 10% gum tragacanth is the most similar to that of the reference marketed preparation. …
Seller Inventory # 9783844323719
- Title
- SUSTAINED RELEASE TABLETS : Use of Natural Gums
- Author
- Barkat Ali Khan
- Publisher
- LAP LAMBERT Academic Publishing
- Publication year
- 2011
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3844323716
- ISBN 13
- 9783844323719
- Item weight
- 191 grams
- Dimensions
- 220x150x8 mm
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